Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, Thailand.
Associated Medical Sciences (AMS)-CMU IRD Research Collaboration, Chiang Mai 50200, Thailand.
Viruses. 2022 Feb 10;14(2):368. doi: 10.3390/v14020368.
Zika virus (ZIKV) epidemiological data in Thailand are limited. We assessed ZIKV IgG seroprevalence among young adults during 1997-2017 and determined factors associated with ZIKV IgG seropositivity. This retrospective laboratory study included randomly selected subjects aged 18-25 years participating in large clinical studies conducted in Thailand during 1997-2017. Stored plasma samples were analyzed for ZIKV IgG using an ELISA test (Anti-Zika Virus IgG, EUROIMMUN, Lübeck, Germany). Sociodemographic, clinical and laboratory data were used in univariable and multivariable analyses to identify factors associated with ZIKV IgG positivity. Of the 1648 subjects included, 1259 were pregnant women, 844 were living with HIV and 111 were living with HBV. ZIKV IgG seroprevalence was similar among the HIV-infected and -uninfected pregnant women (22.8% vs. 25.8%, -value = 0.335) and was overall stable among the pregnant women, with a 25.2% prevalence. Factors independently associated with ZIKV IgG positivity included an age of 23-25 years as compared to 18-20 years, an HIV RNA load below 3.88 log copies/mL and birth in regions outside northern Thailand. Our study shows that a large proportion of the population in Thailand probably remains susceptible to ZIKV infection, which could be the ground for future outbreaks. Continued surveillance of ZIKV spread in Thailand is needed to inform public health policies.
泰国的寨卡病毒（ZIKV）流行病学数据有限。我们评估了 1997-2017 年期间年轻成年人中寨卡病毒 IgG 的血清流行率，并确定了与寨卡病毒 IgG 血清阳性相关的因素。这项回顾性实验室研究包括 1997-2017 年期间在泰国参加大型临床研究的年龄在 18-25 岁的随机选择的受试者。使用 ELISA 试验（Anti-Zika Virus IgG，EUROIMMUN，吕贝克，德国）分析储存的血浆样本中的寨卡病毒 IgG。使用单变量和多变量分析来确定与寨卡病毒 IgG 阳性相关的因素，包括社会人口统计学、临床和实验室数据。在 1648 名受试者中，1259 名是孕妇，844 名是 HIV 感染者，111 名是 HBV 感染者。HIV 感染和未感染的孕妇中寨卡病毒 IgG 血清流行率相似（22.8%与 25.8%，-值=0.335），孕妇中总体稳定，流行率为 25.2%。与寨卡病毒 IgG 阳性独立相关的因素包括年龄为 23-25 岁而不是 18-20 岁、HIV RNA 载量低于 3.88 log 拷贝/mL 和出生在泰国北部以外的地区。我们的研究表明，泰国的很大一部分人口可能仍然容易受到寨卡病毒感染，这可能是未来暴发的基础。需要继续监测泰国寨卡病毒的传播情况，以为公共卫生政策提供信息。
