Department of Rheumatology and Immunology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Department of Rheumatology and Immunology, Beijing Friendship Hospital, Capital Medical University, Beijing, China
RMD Open. 2024 Nov 9;10(4):e004554. doi: 10.1136/rmdopen-2024-004554.
Immunoglobulin 4-related disease (IgG4-RD) is known for its potential to affect nearly every organ, particularly a preference for large and middle-sized arteries when vascular involvement occurs. However, instances of splenic artery aneurysms are exceedingly rare with only two cases reported in the literature. We have summarised the clinical manifestations and laboratory characteristics of the three patients we reported along with the two patients previously reported. It is noteworthy that all five patients had involvement of the salivary glands and only one patient had other arterial involvement. The three patients we reported had no new organ onset or worsening of existing organ involvement and normal or not significantly elevated serum IgG4 levels when the artery aneurysm was identified. These aneurysms may be the result of vascular damage from prior involvement that was not recognised previously. The cases we reported here highlight a potential association between IgG4-RD and concurrent splenic artery aneurysms.
免疫球蛋白 4 相关疾病（IgG4-RD）以其影响几乎所有器官的潜力而闻名，尤其是当发生血管受累时，它更喜欢大中和中等大小的动脉。然而，脾动脉动脉瘤的病例极为罕见，文献中仅报道了两例。我们总结了我们报告的三例患者以及以前报告的两例患者的临床表现和实验室特征。值得注意的是，所有五例患者均有唾液腺受累，只有一例患者有其他动脉受累。我们报告的三例患者在发现动脉动脉瘤时，没有新的器官发病或现有器官受累的恶化，且血清 IgG4 水平正常或没有明显升高。这些动脉瘤可能是先前未被识别的血管损伤的结果。我们报告的这些病例提示 IgG4-RD 与并发的脾动脉动脉瘤之间存在潜在关联。
