Dehghan Alireza, Ardekani Ali, Akabri Mohammadreza, Sadeghi Yasaman, Radmard Amir Reza, Merat Shahin, Khoshnia Masoud, Sharafkhah Maryam, Khuzani Abolfazl Shiravi, Poustchi Hossein, Malekzadeh Reza, Molavi Vardanjani Hossein
MPH Department, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Medical Imaging Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
J Nephrol. 2025 Jan;38(1):181-188. doi: 10.1007/s40620-024-02122-3. Epub 2024 Nov 9.
The relationship between kidney and vascular health is acknowledged, but detailed information is still missing. This study examines the relationship of estimated glomerular filtration rate (eGFR) and carotid intima media thickness, providing insights into the association between atherosclerosis and kidney function.
Participants older than 50 years of age who were part of the PolyIran-L study, a trial nested in the Golestan Cohort Study, were included. The maximal intima media thickness of both common carotid arteries was evaluated using B-mode ultrasonography. Four different cut-off values for abnormal carotid intima media thickness were considered. Correlation of carotid intima media thickness and eGFR was assessed with linear correlation and multivariable binary logistic regression models after adjusting for several confounders.
In total, 1562 participants (750 females, 48%) were included in this population-based study. Assuming the eGFR < 45 [mL/min/1.73 m] group as reference in the crude analysis, those with eGFR ≥ 45 and < 60 [mL/min/1.73 m] showed an association of being less likely to have carotid intima media thickness above the 0.8 cutoff. However, the fully adjusted analysis showed no significant statistical association between carotid intima media thickness and eGFR.
This study did not support the independent association of eGFR and different carotid intima media thickness cutoffs. This pattern may be different in patients with severely decreased eGFR, a subset of cases in which it should be further investigated.
肾脏与血管健康之间的关系已得到认可，但仍缺乏详细信息。本研究探讨估算肾小球滤过率（eGFR）与颈动脉内膜中层厚度之间的关系，以深入了解动脉粥样硬化与肾功能之间的关联。
纳入年龄超过50岁、参与伊朗多中心研究（一项嵌套于戈勒斯坦队列研究中的试验）的参与者。使用B型超声评估双侧颈总动脉的最大内膜中层厚度。考虑了四种不同的颈动脉内膜中层厚度异常临界值。在调整了多个混杂因素后，采用线性相关和多变量二元逻辑回归模型评估颈动脉内膜中层厚度与eGFR的相关性。
本基于人群的研究共纳入1562名参与者（750名女性，占48%）。在粗分析中，以eGFR < 45 [mL/min/1.73 m²]组为参照，eGFR≥45且< 60 [mL/min/1.73 m²]的参与者显示出颈动脉内膜中层厚度高于0.8临界值的可能性较小。然而，完全调整分析显示颈动脉内膜中层厚度与eGFR之间无显著统计学关联。
本研究不支持eGFR与不同颈动脉内膜中层厚度临界值之间的独立关联。在eGFR严重降低的患者中这种模式可能不同，对此类病例的一个亚组应进一步研究。
