颈动脉内膜中层厚度对冠状动脉疾病的诊断作用：荟萃分析。

Diagnostic Role of Carotid Intima-Media Thickness for Coronary Artery Disease: A Meta-Analysis.

机构信息

Imaging Center, Affiliated Hospital of Weifang Medical University, 2428 Yuhe Road, Kuiwen District, Weifang, 261031 Shandong Province, China.

出版信息

Biomed Res Int. 2020 Feb 25;2020:9879463. doi: 10.1155/2020/9879463. eCollection 2020.

BACKGROUND

The present meta-analysis was conducted to confirm whether carotid intima-media thickness (IMT) could serve as an accurate diagnostic method for coronary artery disease (CAD).

METHODS

Databases of PubMed, Google Scholar, and Embase were searched for potential articles. The articles were selected according to inclusion criteria. Pooled sensitivity and specificity with corresponding 95% confidence interval (CI) were used to confirm the diagnostic role of IMT for CAD. and value were used to assess the existence of heterogeneity. and value were used to assess the existence of heterogeneity.

RESULTS

22 eligible articles were selected in the present meta-analysis. Pooled sensitivity and specificity of IMT for diagnosing CAD were 0.68 (0.57-0.77) and 0.70 (0.64-0.75), respectively. The corresponding AUC was 0.74 (0.70-0.78). Subgroup analyses based on cutoff value of IMT were performed. A cutoff value of 1 mm was demonstrated to be much more accurate diagnostic criteria for CAD (sensitivity: 0.66; specificity: 0.79; AUC: 0.80). Sensitivity analysis indicated that the pooled results were robust. Deek's funnel plot indicated no significant publication bias ( value were used to assess the existence of heterogeneity.

CONCLUSION

Carotid IMT may serve as an accurate diagnostic tool. A cutoff value of 1 mm seems to provide much more accurate diagnostic results for CAD.

背景

本荟萃分析旨在证实颈动脉内膜中层厚度（IMT）是否可作为冠心病（CAD）的准确诊断方法。

方法

检索 PubMed、Google Scholar 和 Embase 数据库以获取潜在文章。根据纳入标准选择文章。使用合并的敏感性和特异性及其相应的 95%置信区间（CI）来确认 IMT 对 CAD 的诊断作用。使用和值评估异质性的存在。

结果

本荟萃分析共纳入 22 篇符合条件的文章。IMT 诊断 CAD 的合并敏感性和特异性分别为 0.68（0.57-0.77）和 0.70（0.64-0.75），相应的 AUC 为 0.74（0.70-0.78）。根据 IMT 截断值进行了亚组分析。1mm 的截断值被证明是 CAD 更准确的诊断标准（敏感性：0.66；特异性：0.79；AUC：0.80）。敏感性分析表明，合并结果是稳健的。Deek's 漏斗图表明不存在显著的发表偏倚（值用于评估异质性的存在。