Persing J A, Babler W J, Jane J A, Duckworth P F
Plast Reconstr Surg. 1986 Mar;77(3):369-77. doi: 10.1097/00006534-198603000-00003.
Immobilization of the coronal suture was produced unilaterally in 9-day-old rabbits to determine its effect on subsequent craniofacial development. The suture was immobilized unilaterally by the topical application of methylcyanoacrylate adhesive. Subsequent growth effects on the cranial vault, base, and facial skeleton were assessed by serial radiographic cephalometry. Unilateral coronal suture immobilization resulted in significantly decreased bone growth at the coronal suture (mean 0.95 mm +/- 0.35 SE) when compared to sham-treated control animals (mean 5.06 mm +/- 0.20 SE). Frontonasal suture bone growth contralateral to the immobilized half of the coronal suture, however, was significantly increased. The anterior cranial base became significantly shortened, and orbital asymmetry developed. The pattern of induced abnormalities simulates unilateral coronal synostosis in humans.
在9日龄家兔中单侧固定冠状缝，以确定其对后续颅面发育的影响。通过局部应用氰基丙烯酸甲酯粘合剂单侧固定冠状缝。通过系列放射头颅测量评估对颅顶、颅底和面部骨骼的后续生长影响。与假手术对照组动物（平均5.06 mm±0.20 SE）相比，单侧冠状缝固定导致冠状缝处骨生长显著减少（平均0.95 mm±0.35 SE）。然而，与固定冠状缝一侧相对的额鼻缝骨生长显著增加。前颅底明显缩短，出现眼眶不对称。诱导异常的模式模拟人类单侧冠状缝早闭。
