Ma Shanbo, Han Conghui, Chen Xi, Li Long, Chen Xushuai, Zhang Wei, Wang Jin, Han Fu, Yan Luke, Shi Xiaopeng
Department of Pharmacy, Xijing Hospital, Air Force Medical University, Xi'an 710032, PR China.
School of Materials Science and Engineering, Chang'an University, Xi'an 710064, PR China.
J Control Release. 2025 Jan 10;377:212-222. doi: 10.1016/j.jconrel.2024.10.053. Epub 2024 Nov 20.
Antibacterial hydrogels have generated significant interest for their potential therapeutic applications. Ozone (O₃) is recognized for its antibacterial, anti-inflammatory, immunomodulatory, and anti-hypoxic properties, along with its minimal residual impact. However, the development of sustained O₃-release antibacterial hydrogels has been challenging due to the low solubility and short lifespan of ozone. We present an ozone-loaded emulsion hydrogel (ozonegel), which encapsulates ozonized oil within a nanoclay-poly(methacryloxyethyl sulfobetaine) supramolecular network. This adhesive, self-healing ozonegel achieves high ozone loading (91.3 mmol/kg) and releases O₃ and reactive oxygen species (ROS) over 36 h. It demonstrates broad antibacterial and anti-inflammatory effects, promoting wound healing. The remarkable properties of ozonegels suggest significant potential for advanced biomedical applications.
抗菌水凝胶因其潜在的治疗应用而引起了广泛关注。臭氧（O₃）以其抗菌、抗炎、免疫调节和抗缺氧特性以及最小的残留影响而闻名。然而，由于臭氧的低溶解度和短寿命，开发持续释放臭氧的抗菌水凝胶一直具有挑战性。我们展示了一种负载臭氧的乳液水凝胶（臭氧凝胶），它将臭氧化油封装在纳米粘土 - 聚（甲基丙烯酰氧基乙基磺基甜菜碱）超分子网络中。这种具有粘性、可自愈的臭氧凝胶实现了高臭氧负载量（91.3 mmol/kg），并在36小时内释放O₃和活性氧（ROS）。它具有广泛的抗菌和抗炎作用，促进伤口愈合。臭氧凝胶的卓越性能表明其在先进生物医学应用中具有巨大潜力。
