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实施AO脊柱国际指南后退行性颈椎脊髓病的治疗结果:单中心服务评估

Outcomes for Degenerative Cervical Myelopathy Following Implementation of the AO Spine International Guidelines: A Single-Centre Service Evaluation.

作者信息

Brannigan Jamie, Vellaiyappan Sundar K, Mowforth Oliver D, Magee Joseph, Francis Jibin J, Davies Benjamin M, Kotter Mark R

机构信息

Division of Neurosurgery, Department of Clinical Neurosciences, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.

出版信息

Global Spine J. 2025 May;15(4):2400-2408. doi: 10.1177/21925682241301049. Epub 2024 Nov 10.

DOI:10.1177/21925682241301049
PMID:39523024
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11561916/
Abstract

IntroductionDegenerative cervical myelopathy (DCM) is a syndrome of symptomatic cervical spinal cord compression due to degenerative spinal changes. Until recently there was no formal consensus on exactly which patients are suitable for surgical or conservative management. The AO Spine international guidelines were introduced to address this issue, based on the best available current evidence. However, their implementation into routine clinical practice has not yet been reported. The objective was to evaluate surgical outcomes following the implementation of the AO Spine guidelines at our spinal neurosurgical centre.MethodsA service evaluation was conducted using data collected from electronic healthcare records for 259 patients, with outcomes of interest including change in mJOA score and complications. Data from 193 patients were included in the final analysis.ResultsThere was a mean improvement of the mJOA score by 1.53 points, 1.44 point and 1.92 points at post-operative intervals of 3 months ( < .001), 6 months ( < .001) and 12 months ( < .001). The percentage (number) of patients whose increase in mJOA score was greater than or equal to the minimal clinically importance difference (MCID) was 41% (44/107), 34% (33/96) and 43% (49/114) at these respective time intervals. Intraoperative complications occurred in 28 patients (11.7%). No association was found between BMI and postoperative change in mJOA score.ConclusionOur results are comparable to those from best practice data and suggest adherence to international guidelines provides a service that promotes meaningful recovery for patients with DCM. Therefore, our results offer support for implementation of the AO Spine international guidelines in clinical practice.

摘要

引言

退行性颈椎脊髓病(DCM)是一种由于脊柱退变导致症状性颈脊髓受压的综合征。直到最近,对于哪些患者适合手术或保守治疗尚无正式共识。AO脊柱国际指南基于当前可得的最佳证据应运而生,旨在解决这一问题。然而,其在常规临床实践中的应用情况尚未见报道。本研究旨在评估我们脊柱神经外科中心实施AO脊柱指南后的手术效果。

方法

通过收集259例患者的电子医疗记录进行服务评估,关注的结果包括日本骨科学会(JOA)评分变化和并发症。最终分析纳入了193例患者的数据。

结果

术后3个月(P<0.001)、6个月(P<0.001)和12个月(P<0.001)时,JOA评分平均分别提高了1.53分、1.44分和1.92分。在这些时间点,JOA评分增加大于或等于最小临床重要差异(MCID)的患者百分比(人数)分别为41%(44/107)、34%(33/96)和43%(49/114)。28例患者(11.7%)发生术中并发症。未发现体重指数(BMI)与术后JOA评分变化之间存在关联。

结论

我们的结果与最佳实践数据相当,表明遵循国际指南可为DCM患者提供促进有效康复的服务。因此,我们的结果支持在临床实践中实施AO脊柱国际指南。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa30/12035128/f4a303d91f38/10.1177_21925682241301049-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa30/12035128/2f0f06b462de/10.1177_21925682241301049-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa30/12035128/f4a303d91f38/10.1177_21925682241301049-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa30/12035128/2f0f06b462de/10.1177_21925682241301049-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa30/12035128/f4a303d91f38/10.1177_21925682241301049-fig2.jpg

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本文引用的文献

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Targeting patient recovery priorities in degenerative cervical myelopathy: design and rationale for the RECEDE-Myelopathy trial-study protocol.以退行性颈脊髓病患者的康复重点为目标:RECEDE-Myelopathy 试验研究方案的设计和原理。
BMJ Open. 2023 Mar 7;13(3):e061294. doi: 10.1136/bmjopen-2022-061294.
2
A New Framework for Investigating the Biological Basis of Degenerative Cervical Myelopathy [AO Spine RECODE-DCM Research Priority Number 5]: Mechanical Stress, Vulnerability and Time.一种用于研究退行性颈椎脊髓病生物学基础的新框架[AO脊柱再编码-DCM研究优先级第5号]:机械应力、易损性和时间。
Global Spine J. 2022 Feb;12(1_suppl):78S-96S. doi: 10.1177/21925682211057546.
3
Tremor as a symptom of degenerative cervical myelopathy: a systematic review.
震颤作为退行性颈椎脊髓病的症状:系统评价。
Br J Neurosurg. 2022 Jun;36(3):340-345. doi: 10.1080/02688697.2022.2033701. Epub 2022 Feb 8.
4
Determinants of quality of life in degenerative cervical myelopathy: a systematic review.退行性颈脊髓病生活质量的决定因素:系统评价。
Br J Neurosurg. 2023 Feb;37(1):71-81. doi: 10.1080/02688697.2021.1999390. Epub 2021 Nov 18.
5
Moving Beyond the Neck and Arm: The Pain Experience of People With Degenerative Cervical Myelopathy Who Have Pain.超越颈部和手臂:患有退行性颈椎病且伴有疼痛者的疼痛体验
Global Spine J. 2022 Sep;12(7):1434-1442. doi: 10.1177/2192568220986143. Epub 2021 Feb 25.
6
Outcomes of Degenerative Cervical Myelopathy From The Perspective of Persons Living With the Condition: Findings of a Semistructured Interview Process With Partnered Internet Survey.从退行性颈椎脊髓病患者的角度看其治疗结果:半结构化访谈过程与配套网络调查的结果
Global Spine J. 2022 Apr;12(3):432-440. doi: 10.1177/2192568220953811. Epub 2020 Nov 18.
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Global Spine J. 2022 May;12(4):638-645. doi: 10.1177/2192568220961357. Epub 2020 Oct 1.
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