In this chapter, we introduce the topic of the brain connectome, consisting of the complete set of both the structural and functional connections of the brain. Connectomic information and the large-scale network architecture of the brain provide an improved understanding of the organization and functional relevance of human cortical and subcortical anatomy. We discuss various analytical methods to both identify and interpret structural and functional connectivity data. In turn, we discuss how these data provide significant clinical promise for neurosurgery, neurology, and psychiatry in that more informed decisions can be made based on connectomic information. These data can provide safer and more informed network-based neurosurgery for brain tumor patients and even offer the possibility to modulate the brain connectome.