梗死早期有害的抗炎性巨噬细胞募集：解析白细胞介素-6/单核细胞趋化蛋白-1/信号转导和转录激活因子3轴

Deleterious Anti-Inflammatory Macrophage Recruitment in Early Post-Infarction Phase: Unraveling the IL-6/MCP-1/STAT3 Axis.

作者信息

Paccalet Alexandre, Badawi Sally, Pillot Bruno, Augeul Lionel, Mechtouff Laura, Harhous Zeina, Gouriou Yves, Paillard Mélanie, Breuilly Marine, Amaz Camille, Varillon Yvonne, Leboube Simon, Brun Camille, Prieur Cyril, Rioufol Gilles, Mewton Nathan, Ovize Michel, Bidaux Gabriel, Bochaton Thomas, Crola Da Silva Claire

机构信息

Laboratoire CarMeN-IRIS Team, INSERM, INRA, Université Claude Bernard Lyon-1, INSA-Lyon, University of Lyon, Bron, France.

CIQLE, LyMIC, LABEX CORTEX, Université Claude Bernard Lyon 1, Structure Fédérative de Recherche santé Lyon-Est CNRS UAR3453/Inserm US7, Lyon, France.

出版信息

JACC Basic Transl Sci. 2024 Apr 24;9(5):593-604. doi: 10.1016/j.jacbts.2024.01.019. eCollection 2024 May.

Using a translational approach with an ST-segment myocardial infarction (STEMI) cohort and mouse model of myocardial infarction, we highlighted the role of the secreted IL-6 and MCP-1 cytokines and the STAT3 pathway in heart macrophage recruitment and activation. Cardiac myocytes secrete IL-6 and MCP-1 in response to hypoxic stress, leading to a recruitment and/or polarization of anti-inflammatory macrophages via the STAT3 pathway. In our preclinical model of myocardial infarction, neutralization of IL-6 and MCP-1 or STAT3 pathway reduced infarct size. Together, our data demonstrate that anti-inflammatory macrophages can be deleterious in the acute phase of STEMI.