Gusev E I, Sheliakina L A, Bogolepov N N, Burd G S, Vorob'eva T V
Zh Nevropatol Psikhiatr Im S S Korsakova. 1986;86(1):38-42.
Ultrastructural aspects of the secondary brain stem syndrome in patients with hemorrhages and infarcts in the brain hemispheres are considered. The secondary brain stem syndrome is manifested by diverse clinical symptomatology suggestive of dysfunction of different levels of the brain stem: a diminished level of awakening, oculomotor disturbances, changes in the muscle tone and reflexes, cardiorespiratory and other vegetative disorders. Examining the reticular formation of the brain stem under the electron microscope the authors revealed changes in neurons in the form of chromatolysis, an increase in the cellular cytoplasm of the number of lipid inclusions and lysosomes, swelling of mitochondria and (less frequently) the appearance of cells with an elevated osmiophilia of the cytoplasm. Also observed was a systemic increase in lysosomes and lipid granules in capillary structures, and in glial and nervous cells. The pathogenetic factors of secondary brain stem syndrome are discussed.
本文探讨了大脑半球出血和梗死患者继发性脑干综合征的超微结构特征。继发性脑干综合征表现为多种临床症状，提示脑干不同水平功能障碍：觉醒水平降低、动眼神经紊乱、肌张力和反射改变、心肺及其他自主神经紊乱。作者通过电子显微镜检查脑干网状结构，发现神经元出现染色质溶解、细胞浆中脂质包涵体和溶酶体数量增加、线粒体肿胀以及（较少见）细胞质嗜锇性增强的细胞。还观察到毛细血管结构、神经胶质细胞和神经细胞中溶酶体和脂质颗粒的系统性增加。文中讨论了继发性脑干综合征的发病因素。
