E Yuyu, Chang Zeyu, Su Weiyin, Li Wen, Li Pengfei, Lei Fuhou, Yao Xi, Yuan Shengguang, Li Jie, Zhang Fenglun, Jiang Jianxin, Wang Kun
Department of Chemistry and Chemical Engineering, Beijing Forestry University, MOE Engineering Research Center of Forestry Biomass Materials and Bioenergy, Beijing 100083, China.
Key Laboratory of Chemistry and Engineering of Forest Products, State Ethnic Affairs Commission, Guangxi Key Laboratory of Chemistry and Engineering of Forest Products, Guangxi Collaborative Innovation Center for Chemistry and Engineering of Forest Products, Guangxi Minzu University, Nanning 530006, China.
Int J Biol Macromol. 2024 Dec;283(Pt 1):137279. doi: 10.1016/j.ijbiomac.2024.137279. Epub 2024 Nov 10.
Design and development of a multifunctional wound dressing with self-healing, adhesive, and antibacterial properties to attain optimal wound closure efficiency are highly desirable in clinical applications. Nevertheless, conventional hydrogels face significant barriers in their mechanical strength, adhesive performance, and antibacterial properties. Herein, a tough hydrogel based on aldehyde-grafted galactomannan was synthesized through radical copolymerization and Schiff base reaction, incorporating hyaluronic acid, acrylamide, and the zwitterionic monomer to create a multi-crosslinked structure. The multiple crosslink structure pattern consisting of multiple hydrogen bonding, ionic interactions, reversible Schiff bases bonds, and molecular chain entanglement endowed this hydrogel with multiple functionalities, including high tensile strength (25 kPa), tensile strain (2200 %), toughness (391.59 kJ/m), and Young's modulus (9.77 kPa). The presence of catechol groups and zwitterionic groups endow hydrogels with outstanding adhesion strength (42.21 kPa), which satisfied the adhesive demand for the ample motion of specific areas. The zwitterionic monomer provided long-lasting antibacterial properties and promoted migration and growth of negatively charged cells, capable of establishing efficient antibacterial barriers and serving as wound dressing. The in vivo and vitro experiments manifested that the optimized hydrogel demonstrated an inconspicuous inflammatory response, facilitating rapid healing of full-thickness skin wound in rat models. Therefore, this work provides a promising strategy and an ideal candidate for wound healing dressings in treating infected skin wounds.
设计和开发一种具有自愈、粘附和抗菌特性的多功能伤口敷料，以实现最佳的伤口闭合效率，在临床应用中是非常可取的。然而，传统水凝胶在机械强度、粘附性能和抗菌性能方面面临重大障碍。在此，通过自由基共聚和席夫碱反应合成了一种基于醛基接枝半乳甘露聚糖的坚韧水凝胶，其中加入了透明质酸、丙烯酰胺和两性离子单体，形成了多重交联结构。由多重氢键、离子相互作用、可逆席夫碱键和分子链缠结组成的多重交联结构模式赋予了这种水凝胶多种功能，包括高拉伸强度（25 kPa）、拉伸应变（2200%）、韧性（391.59 kJ/m）和杨氏模量（9.77 kPa）。邻苯二酚基团和两性离子基团的存在赋予水凝胶出色的粘附强度（42.21 kPa），满足了特定区域充分活动的粘附需求。两性离子单体提供了持久的抗菌性能，并促进带负电荷细胞的迁移和生长，能够建立有效的抗菌屏障并用作伤口敷料。体内和体外实验表明，优化后的水凝胶表现出不明显的炎症反应，有助于大鼠模型中全层皮肤伤口的快速愈合。因此，这项工作为治疗感染性皮肤伤口的伤口愈合敷料提供了一种有前景的策略和理想的候选材料。
