Liu Yang, Wang Liu, Wen Dawei, Deng Zhonghua, Wu Zhifang, Li Sijin, Li Yongfeng
Department of Nuclear Medicine, First Hospital of Shanxi Medical University, Shanxi Medical University, Taiyuan, 030001, Shanxi, China.
Shanxi Key Laboratory of Molecular Imaging, Shanxi Medical University, Taiyuan, 030001, Shanxi, China.
Sci Rep. 2025 Apr 11;15(1):12490. doi: 10.1038/s41598-025-93310-z.
This study aims to develop a composite hydrogel consisting of nano silver (Ag) and graphene oxide (GO) for use as a skin wound dressing. We prepared nanosilver/graphene oxide composite hydrogels by incorporating nanosilver and graphene oxide into kaolin-reinforced, gelatin-based hydrogels. Tests were conducted on the hydrogel's water vapor permeability, mechanical properties, infrared warming performance and bacteriostatic properties under infrared light. The results indicated that kaolin enhanced the water vapor permeability and mechanical properties of the gelatin-based hydrogels. Moreover, the maximum fracture stress and strain of the hydrogel were elevated to 51.16 kPa and 1152.78% by GO, respectively. Furthermore, the modified Ag/GO hydrogels exhibited superior photothermal conversion and infrared bacteriostatic properties. This research offers valuable insights for the clinical repair of wounds and the design of new skin wound dressings, making these materials promising for such applications.
本研究旨在开发一种由纳米银(Ag)和氧化石墨烯(GO)组成的复合水凝胶,用作皮肤伤口敷料。我们通过将纳米银和氧化石墨烯掺入高岭土增强的明胶基水凝胶中来制备纳米银/氧化石墨烯复合水凝胶。对该水凝胶在红外光下的水蒸气透过率、力学性能、红外升温性能和抑菌性能进行了测试。结果表明,高岭土提高了明胶基水凝胶的水蒸气透过率和力学性能。此外,氧化石墨烯分别将水凝胶的最大断裂应力和应变提高到了51.16 kPa和1152.78%。此外,改性后的银/氧化石墨烯水凝胶表现出优异的光热转换和红外抑菌性能。本研究为伤口的临床修复和新型皮肤伤口敷料的设计提供了有价值的见解,使这些材料在这类应用中具有广阔前景。