Lai Clara Kit Nam, DeCicco Jamie, Cadena Semanate Ramiro, Kara Ali M, Tran Andrew H, Kim Hee Kyung Jenny, Abraham Abel, Lee Michael, Haurin Sarah, Prasad Rachna, Kosic Rachel, El-Hayek Kevin
Division of General Surgery, The MetroHealth System/Case Western Reserve University, Cleveland, OH.
Cleveland Clinic Lerner College of Medicine of Case Western Reverse University, Cleveland, OH. Electronic address: https://twitter.com/jamiepdecicco.
Surgery. 2025 Mar;179:108887. doi: 10.1016/j.surg.2024.07.088. Epub 2024 Nov 12.
Mounting evidence favors one-stage laparoscopic cholecystectomy with common bile duct exploration over endoscopic retrograde cholangiopancreatography with cholecystectomy for choledocholithiasis. However, laparoscopic cholecystectomy with common bile duct exploration remains underused. In 2020, our center initiated a laparoscopic cholecystectomy with common bile duct exploration program for choledocholithiasis. This study compares the experience and outcomes of laparoscopic cholecystectomy with common bile duct exploration compared with endoscopic retrograde cholangiopancreatography with cholecystectomy at a safety net hospital.
This single-center, retrospective study analyzed data from 179 patients admitted with choledocholithiasis from 2019 to 2023. Demographics, preoperative investigations, intraoperative details, and postoperative outcomes were evaluated.
The study included 179 patients (55.6 ± 21.0 years, 66% female) with American Society of Anesthesiologists Physical Status Classification System score III (II-III) and body mass index 29 kg/m (25.8-35.5 kg/m). Of these, 148 underwent endoscopic retrograde cholangiopancreatography with cholecystectomy and 31 underwent laparoscopic cholecystectomy with common bile duct exploration. Demographic and preoperative data were similar between groups. Laparoscopic cholecystectomy with common bile duct exploration achieved a 74.2% success rate. Laparoscopic cholecystectomy with common bile duct exploration's average operative time was 180 (139-213) minutes, with a 3.2% postoperative bile leak and 35.4% requiring postoperative ERCP. Median lengths of stay were 3 (1-4) for laparoscopic cholecystectomy with common bile duct exploration and 4 days (3-7) for endoscopic retrograde cholangiopancreatography with cholecystectomy (Z = -3.16, P = .002). The number of readmissions were 1.2 ± 0.4 for laparoscopic cholecystectomy with common bile duct exploration and 1.9 ± 1.3 for endoscopic retrograde cholangiopancreatography with cholecystectomy (t = 1.43, P = .08). Additional procedures for choledocholithiasis were performed in 36% of laparoscopic cholecystectomy with common bile duct exploration and 79% of ERCP + LC cases (χ = 21.7, P < .0001).
The study highlights challenges in implementing laparoscopic cholecystectomy with common bile duct exploration at a safety net hospital. Results support laparoscopic cholecystectomy with common bile duct exploration over endoscopic retrograde cholangiopancreatography, with cholecystectomy, with shorter stays, fewer readmissions, and fewer additional procedures reported. Laparoscopic cholecystectomy with common bile duct exploration remains underused, with only 17.3% of patients who underwent one-stage laparoscopic cholecystectomy with common bile duct exploration. Further research is needed for laparoscopic cholecystectomy with common bile duct exploration's expansion as the superior choledocholithiasis treatment.
越来越多的证据表明,对于胆总管结石,一期腹腔镜胆囊切除术联合胆总管探查术优于内镜逆行胰胆管造影术联合胆囊切除术。然而,腹腔镜胆囊切除术联合胆总管探查术的应用仍然不足。2020年,我们中心启动了一项针对胆总管结石的腹腔镜胆囊切除术联合胆总管探查术项目。本研究比较了在一家安全网医院中,腹腔镜胆囊切除术联合胆总管探查术与内镜逆行胰胆管造影术联合胆囊切除术的经验和结果。
这项单中心回顾性研究分析了2019年至2023年收治的179例胆总管结石患者的数据。评估了人口统计学、术前检查、术中细节和术后结果。
该研究纳入了179例患者(年龄55.6±21.0岁,66%为女性),美国麻醉医师协会身体状况分类系统评分为III级(II-III级),体重指数为29kg/m²(25.8-35.5kg/m²)。其中,148例接受了内镜逆行胰胆管造影术联合胆囊切除术,31例接受了腹腔镜胆囊切除术联合胆总管探查术。两组之间的人口统计学和术前数据相似。腹腔镜胆囊切除术联合胆总管探查术的成功率为74.2%。腹腔镜胆囊切除术联合胆总管探查术的平均手术时间为180(139-213)分钟,术后胆漏发生率为3.2%,35.4%的患者术后需要进行内镜逆行胰胆管造影术。腹腔镜胆囊切除术联合胆总管探查术的中位住院时间为3(1-4)天,内镜逆行胰胆管造影术联合胆囊切除术的中位住院时间为4天(3-7)天(Z=-3.16,P=0.002)。腹腔镜胆囊切除术联合胆总管探查术的再入院次数为1.2±0.4次,内镜逆行胰胆管造影术联合胆囊切除术的再入院次数为1.9±1.3次(t=1.43,P=0.08)。36%的腹腔镜胆囊切除术联合胆总管探查术患者和79%的内镜逆行胰胆管造影术联合胆囊切除术患者因胆总管结石进行了额外的手术(χ²=21.7,P<0.0001)。
该研究突出了在安全网医院实施腹腔镜胆囊切除术联合胆总管探查术的挑战。结果支持腹腔镜胆囊切除术联合胆总管探查术优于内镜逆行胰胆管造影术联合胆囊切除术,前者住院时间更短、再入院次数更少、额外手术更少。腹腔镜胆囊切除术联合胆总管探查术的应用仍然不足,仅17.3%的患者接受了一期腹腔镜胆囊切除术联合胆总管探查术。需要进一步研究以扩大腹腔镜胆囊切除术联合胆总管探查术作为胆总管结石的更优治疗方法的应用。