Davidson G P, Kirubakaran C P, Ratcliffe G, Cooper D M, Robb T A
Acta Paediatr Scand. 1986 Jan;75(1):145-50. doi: 10.1111/j.1651-2227.1986.tb10171.x.
We performed pancreatic function tests on sixty-five cystic fibrosis (CF), and eleven control children. The technique used continuous IV infusion of cholecystokinin and secretin, with duodenal juice collection over a 90 min period, and was made quantitative by continuous duodenal infusion and distal collection of an unabsorbable marker (bromosulphthalein). Some CF patients had near normal pancreatic enzyme outputs, some had impaired but measurable levels, but most (79%) had almost absent trypsin secretion. CF children with better pancreatic function, were younger and more likely to be male. All controls showed a large increase in bicarbonate concentration and secretion rate per kilogram body weight during the test, but most children with CF (96.5%) did not. Because two of our CF patients had water and bicarbonate secretion within the control range, this finding does not exclude the diagnosis of CF. Sodium, potassium and chloride ion secretion in CF patients was lower than controls but overlap occurred. We found a linear correlation between acinar and tubular secretion in CF patients which indicates that there is probably not a primary genetic defect in pancreatic bicarbonate secretion in CF.
我们对65名囊性纤维化（CF）患儿和11名对照儿童进行了胰腺功能测试。该技术采用持续静脉输注胆囊收缩素和促胰液素，在90分钟内收集十二指肠液，并通过持续十二指肠输注和不可吸收标记物（溴磺酞）的远端收集进行定量分析。一些CF患者的胰腺酶输出接近正常，一些患者的胰腺酶水平受损但仍可测量，但大多数（79%）患者的胰蛋白酶分泌几乎缺失。胰腺功能较好的CF儿童年龄较小，且更可能为男性。所有对照儿童在测试期间每千克体重的碳酸氢盐浓度和分泌率均大幅增加，但大多数CF儿童（96.5%）未出现这种情况。由于我们的两名CF患者的水和碳酸氢盐分泌在对照范围内，这一发现并不能排除CF的诊断。CF患者的钠、钾和氯离子分泌低于对照组，但存在重叠。我们发现CF患者的腺泡和导管分泌之间存在线性相关性，这表明CF患者胰腺碳酸氢盐分泌可能不存在原发性基因缺陷。
