Kopelman H, Corey M, Gaskin K, Durie P, Weizman Z, Forstner G
Division of Gastroenterology, Hospital for Sick Children, Toronto, Ontario, Canada.
Gastroenterology. 1988 Aug;95(2):349-55. doi: 10.1016/0016-5085(88)90490-8.
Pancreatic fluid and electrolyte secretion was assessed in 56 patients with cystic fibrosis (CF) and 56 non-CF control subjects undergoing pancreatic function testing while stimulated with cholecystokinin and secretin. Both CF patients and control subjects exhibited a wide range of pancreatic function. Fluid and trypsin outputs were positively correlated in both groups. Fluid output in CF subjects was significantly lower, however, than that of control subjects at any given level of trypsin output. Sodium, bicarbonate, and chloride secretions were all significantly decreased in CF subjects. Bicarbonate and chloride were important determinants of fluid secretion, but at any given bicarbonate or chloride output CF subjects secreted significantly less fluid than control subjects. When bicarbonate and chloride were analyzed as simultaneous predictor variables, adjusted fluid secretion was not significantly different in CF and control subjects. Diminished fluid secretion in CF subjects is therefore caused by impaired chloride, as well as bicarbonate, secretion.
在56例囊性纤维化（CF）患者和56例接受胰功能测试的非CF对照受试者中，在胆囊收缩素和促胰液素刺激下评估胰液和电解质分泌。CF患者和对照受试者均表现出广泛的胰功能范围。两组的液体和胰蛋白酶输出均呈正相关。然而，在任何给定的胰蛋白酶输出水平下，CF受试者的液体输出均显著低于对照受试者。CF受试者的钠、碳酸氢盐和氯分泌均显著减少。碳酸氢盐和氯是液体分泌的重要决定因素，但在任何给定的碳酸氢盐或氯输出水平下，CF受试者分泌的液体均显著少于对照受试者。当将碳酸氢盐和氯作为同时预测变量进行分析时，CF和对照受试者的校正液体分泌无显著差异。因此，CF受试者液体分泌减少是由氯分泌受损以及碳酸氢盐分泌受损所致。
