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在尸体模型中,用强化生物诱导植入物增强的内侧髌股韧带在零时与天然内侧髌股韧带在生物力学上相似。

Medial Patellofemoral Ligament Augmented With a Reinforced Bioinductive Implant Is Biomechanically Similar to the Native Medial Patellofemoral Ligament at Time Zero in a Cadaveric Model.

作者信息

Millan Sean Mc, Sherman Seth, Brown Zachary R, Brewer Erik, Ford Elizabeth

机构信息

Virtua Health System, Marlton, New Jersey, U.S.A.

Stanford University, Redwood City, California, U.S.A.

出版信息

Arthrosc Sports Med Rehabil. 2024 Jul 14;6(5):100975. doi: 10.1016/j.asmr.2024.100975. eCollection 2024 Oct.

Abstract

PURPOSE

To biomechanically compare primary medial patellofemoral ligament (MPFL) repair (MPFLr) augmented with a reinforced bioinductive implant (RBI) to the native MPFL ligament and a semitendinosus (semi-T) MPFL reconstruction (MPFLR) at time zero.

METHODS

Four fresh-frozen matched pair cadavers (8 knees) were used to biomechanically compare the native MPFL to augmented MPFLr (n = 4) and semi-T MPFLR (n = 4). The native MPFL (n = 8) was isolated, preserving the femoral and patellar attachments, and pulled to failure. The semi-T was harvested from 1 of the matched pairs and whipstitched, as was a 250-mm × 5-mm RBI. A standard double-bundle docking technique was utilized. The patella was potted and mechanically pulled parallel to the transverse axis until failure in both cohorts. Cyclic creep, load and displacement at failure, failure mode, and stiffness were recorded.

RESULTS

Failure load was highest in the RBI with repair group (287 ± 130 N) compared to the native MPFL (219 ± 64 N) and the semi-T group (84 ± 29 N). No statistically significant difference in failure load between the RBI augmentation with repair group and the native ligament ( = .19) were found. The semi-T reconstruction group failed at the least amount of displacement (7.93 ± 3.4 mm) compared to the native MPFL (20.9 ± 9 mm) ( < .01) and the RBI with repair group (33.2 ± 17.7 mm) ( < .02). At 10 mm of displacement, the RBI group (8.3 ± 1.2 N/mm) demonstrated stiffness in the midrange compared to the native MPFL (14.1 ± 7.1 N/mm). Early anchor/tendon pullout failure on the patella side was noted in the semi-T group compared to the RBI group. One reconstruction was excluded from analysis due to poor bone quality.

CONCLUSIONS

No statistically significant difference was seen between the augmented MPFL repair and the native MPFL in load-to-failure testing. The augmented MPFL repair was observed to have biomechanical properties similar to the native MPFL. MPFLr with RBI augmentation provided consistent stiffness at clinically relevant displacement.

CLINICAL RELEVANCE

Primary MPFL repair and reconstruction using the semi-T graft, while effective, are nevertheless imperfect procedures. MPFL repair has been shown to have higher instability recurrence rates, while the stiffness profile of MPFLR with semi-T is higher than the native MFPL and may lead to knee stiffness, loss of motion, or cartilage damage. The results of this time-zero biomechanical study indicate that the use of an RBI for augmentation of a primary MPFL repair may be a viable alternative to traditional MPFL repair or reconstruction using a semi-T graft.

摘要

目的

在零时对使用增强型生物诱导植入物(RBI)增强的原发性内侧髌股韧带(MPFL)修复术(MPFLr)与天然MPFL韧带和半腱肌(半T)MPFL重建术(MPFLR)进行生物力学比较。

方法

使用四具新鲜冷冻的配对尸体(8个膝关节)对天然MPFL与增强型MPFLr(n = 4)和半T MPFLR(n = 4)进行生物力学比较。分离出天然MPFL(n = 8),保留股骨和髌骨附着点,并拉伸至失效。从一对配对尸体中的一具获取半T并进行锁边缝合,对一个250毫米×5毫米的RBI也进行同样操作。采用标准的双束对接技术。将髌骨固定并沿横轴平行方向进行机械拉伸,直至两组均失效。记录循环蠕变、失效时的载荷和位移、失效模式及刚度。

结果

与天然MPFL(219±64 N)和半T组(84±29 N)相比,RBI修复组的失效载荷最高(287±130 N)。在RBI增强修复组与天然韧带之间未发现失效载荷有统计学显著差异(P = 0.19)。与天然MPFL(20.9±9毫米)(P < 0.01)和RBI修复组(33.2±17.7毫米)(P < 0.02)相比,半T重建组在最小位移量(7.93±3.4毫米)时失效。在10毫米位移时,RBI组(8.3±1.2 N/mm)的刚度处于中等范围,相比之下天然MPFL为(14.1±7.1 N/mm)。与RBI组相比,半T组在髌骨侧出现早期锚钉/肌腱拔出失效。由于骨质不佳,有一次重建被排除在分析之外。

结论

在失效载荷测试中,增强型MPFL修复与天然MPFL之间未发现统计学显著差异。观察到增强型MPFL修复具有与天然MPFL相似的生物力学特性。使用RBI增强的MPFLr在临床相关位移时提供了一致的刚度。

临床意义

使用半T移植物进行原发性MPFL修复和重建虽然有效,但仍是不完善的手术。已表明MPFL修复有更高的不稳定复发率,而半T的MPFLR的刚度曲线高于天然MFPL,可能导致膝关节僵硬、活动丧失或软骨损伤。这项零时生物力学研究结果表明,使用RBI增强原发性MPFL修复可能是传统MPFL修复或使用半T移植物重建的可行替代方法。

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