Sharma Prashish, Saurav Sushmita, Tabassum Zeba, Sood Bhawana, Kumar Anil, Malik Tabarak, Mohan Anand, Girdhar Madhuri
School of Bioengineering and Biosciences, Lovely Professional University Phagwara 144401 Punjab India.
School of Physical and Chemical Engineering, Lovely Professional University Phagwara 144401 Punjab India.
RSC Adv. 2024 Nov 12;14(49):36226-36245. doi: 10.1039/d4ra06092j. eCollection 2024 Nov 11.
Inflammatory diseases exert a significant influence on the periodontium, serving as a primary contributor to the development of periodontitis. The advancement of periodontitis, characterized by manifestations, such as gingival recession, increased periodontal pocket depth and resorption across the alveolar bone, cementum and periodontal ligaments, poses a significant risk of dental detachment. Untreated or delayed treatment further worsens these deleterious outcomes. This emphasizes the critical importance of timely and effective interventions in reducing the consequences associated with periodontitis. Addressing these challenges requires to focus on the fabrication of bioactive materials, particularly scaffolds, as pivotal elements in tissue engineering processes aimed at alveolar bone regeneration. The incorporation of natural polymers, particularly their amalgamation with clays and clay minerals, such as montmorillonite and LAPONITE®, has been identified as a prospective pathway for advancing biomaterials in the realm of dentistry. This amalgamation holds significant potential for the production of biomaterials with enhanced properties, underscoring its relevance and applicability in dental research. This review paper explores the current advancements in natural polymer-based biomaterials employed in various dental applications, including oral caries, regenerative medicine and alveolar bone regeneration. The principal aim of this investigation is to briefly compile and present the existing knowledge while updating information on the utilization of natural polymers in the formulation of biomaterials. Additionally, the paper aims to elucidate their applications within contemporary research trends and developments in the field of odontology. This article extensively delves into pertinent research to assess the progress of nanotechnology in the context of tissue regeneration and the treatment of oral diseases.
炎症性疾病对牙周组织有重大影响,是牙周炎发展的主要促成因素。牙周炎的进展表现为牙龈退缩、牙周袋深度增加以及牙槽骨、牙骨质和牙周韧带的吸收,这会带来牙齿脱落的重大风险。未经治疗或治疗延迟会使这些有害后果进一步恶化。这强调了及时有效干预对于减少与牙周炎相关后果的至关重要性。应对这些挑战需要专注于生物活性材料特别是支架的制造,作为旨在促进牙槽骨再生的组织工程过程中的关键要素。天然聚合物的掺入特别是它们与粘土及粘土矿物(如蒙脱石和锂皂石®)的结合,已被确定为推动牙科领域生物材料发展的一条潜在途径。这种结合对于生产具有增强性能的生物材料具有巨大潜力,突出了其在牙科研究中的相关性和适用性。这篇综述文章探讨了用于各种牙科应用(包括口腔龋齿、再生医学和牙槽骨再生)的基于天然聚合物的生物材料目前取得的进展。这项研究的主要目的是简要汇编和呈现现有知识,同时更新关于天然聚合物在生物材料配方中应用的信息。此外,本文旨在阐明它们在当代牙科学研究趋势和发展中的应用。本文广泛深入研究相关研究以评估纳米技术在组织再生和口腔疾病治疗背景下的进展。