Zhou Bin, Hu Chao, Li Haoyang, Ye Xiangyi, Wen Baohua, Zhou Zhangkai, Cai Jingxuan, Zhou Jianhua
Key Laboratory of Sensing Technology and Biomedical Instruments of Guangdong Province, School of Biomedical Engineering, Shenzhen Campus of Sun Yat-sen University, 518107, Shenzhen, China.
School of Physics, State Key Laboratory of Optoelectronic Materials and Technologies, Sun Yat-sen University, 510275, Guangzhou, China.
Microsyst Nanoeng. 2024 Nov 13;10(1):168. doi: 10.1038/s41378-024-00793-3.
Surface lattice resonances (SLR) have been demonstrated to enhance the sensitivity and reduce the full width at half maximum (FWHM) of the plasmonic resonances. However, their widespread application in immunoassays has been hindered by limitations of high structural defect sensitivity and fabrication costs. Here, we design a novel three-layer cylindrical SLR array that exhibits high tolerance against structural defects, which would facilitate straightforward fabrication. By integrating metal evaporation and nanoimprint lithography, we demonstrate the replication of the SLR array with exceptional quality. Theoretical simulations indicate that the resonance dips of these arrays exhibit are not sensitive to various structural defects. The experimental results reveal that the FWHM of these arrays can be as low as 5.1 nm while maintaining robust resonance characteristics. Furthermore, we demonstrated the high spectral sensitivity of the SLR array, which enabled the detection of immunoglobulin G (IgG) at concentrations as low as 609 pg/mL. These findings emphasize the potential of the defect-insensitive SLR array as a highly scalable immunoassay platform with exceptional performance.
表面晶格共振（SLR）已被证明可提高等离子体共振的灵敏度并减小半高宽（FWHM）。然而，其在免疫分析中的广泛应用受到高结构缺陷敏感性和制造成本的限制。在此，我们设计了一种新型的三层圆柱形SLR阵列，该阵列对结构缺陷具有高耐受性，这将便于直接制造。通过结合金属蒸发和纳米压印光刻技术，我们展示了具有卓越质量的SLR阵列的复制。理论模拟表明，这些阵列的共振凹陷对各种结构缺陷不敏感。实验结果表明，这些阵列的FWHM可低至5.1nm，同时保持稳健的共振特性。此外，我们展示了SLR阵列的高光谱灵敏度，能够检测低至609pg/mL浓度的免疫球蛋白G（IgG）。这些发现强调了对缺陷不敏感的SLR阵列作为具有卓越性能的高度可扩展免疫分析平台的潜力。
