Do Nhi Ma
Arizona School of Health Sciences, A.T. Still University, Ormond Beach, FL, USA (NMD).
Am J Lifestyle Med. 2024 Oct 22:15598276241292605. doi: 10.1177/15598276241292605.
The microbiome connects the gut health to the rest of the body's organs, including the skin. The pathophysiology of intestinal dysbiosis leads to the expression "leaky gut." Ongoing speculations are aimed at restoring the gut microbiota via modulating lifestyle habits to prevent and potentially reverse autoimmunity. This review finds the connections between gut dysbiosis and skin conditions. It also collects evidence of some lifestyle pillars that influence the gut microbiome including dietary intakes, exercise, sleep, stress, and toxin exposures. It addresses why maintaining a healthy intestinal microbiome is important for the health of all organs in the human host. More people are affected by gut dysbiosis resulting in pro-inflammatory effects on different organs, like the cutaneous tissue, one of the largest epithelial surfaces. It is essential to take care of the gut health because this is where most of the immune system resides. The connection between the intestinal tract with its microbiota and the cutaneous system with its microbiota seems to be mediated by the immune system of the human host. Therefore, this review enhances the understanding of the research on the gut microbiome, its relationship to skin health, and the interplay between the gut and various autoimmune cutaneous conditions.
微生物群将肠道健康与身体的其他器官（包括皮肤）联系起来。肠道生态失调的病理生理学导致了“肠漏”这一表述。目前的推测旨在通过调节生活习惯来恢复肠道微生物群，以预防并可能逆转自身免疫。本综述发现了肠道生态失调与皮肤疾病之间的联系。它还收集了一些影响肠道微生物群的生活方式要素的证据，包括饮食摄入、运动、睡眠、压力和毒素暴露。它阐述了为何维持健康的肠道微生物群对人类宿主所有器官的健康都很重要。越来越多的人受到肠道生态失调的影响，并对不同器官（如最大的上皮表面之一的皮肤组织）产生促炎作用。关注肠道健康至关重要，因为这里是大多数免疫系统所在之处。肠道及其微生物群与皮肤系统及其微生物群之间的联系似乎是由人类宿主的免疫系统介导的。因此，本综述增进了对肠道微生物群研究、其与皮肤健康的关系以及肠道与各种自身免疫性皮肤疾病之间相互作用的理解。
