Potashkin Judith A, Kim Namhee
Cellular and Molecular Pharmacology Department, Center for Neurodegenerative Diseases and Therapeutics, The Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA.
Michael Reese Foundation Center for Health Equity Research, Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA.
Am J Lifestyle Med. 2024 Sep 23:15598276241285806. doi: 10.1177/15598276241285806.
Approximately 10 million individuals in the United States have osteoporosis and 44 million have low bone mineral density which puts them at risk for bone breaks. This presents a large burden on our health care system since about one-quarter of hip fracture patients never regain full function, need nursing care, and, for those over age 50, 24% die within one year. Oral bisphosphonates are often used as first-line therapy for the treatment of osteoporosis; however, patients frequently experience significant side effects. In addition, bisphosphonates inhibit bone loss by initiating apoptosis in osteoclasts that remove old bone, thus allowing old bone to accumulate and slowing the activity of osteoblasts that create new bone, thereby affecting bone quality. As an alternative, a bone-friendly lifestyle, including calcium and vitamin D consumption, exercise, smoking cessation, and a decrease in alcohol intake, may reduce bone loss. This case report describes lifestyle changes that included diet and exercise that increased bone mineral density in two years in a post-menopausal woman with no negative side effects.
美国约有1000万人患有骨质疏松症,4400万人骨矿物质密度低,这使他们面临骨折风险。这给我们的医疗保健系统带来了巨大负担,因为约四分之一的髋部骨折患者无法完全恢复功能,需要护理,而且对于50岁以上的患者,24%在一年内死亡。口服双膦酸盐通常用作治疗骨质疏松症的一线疗法;然而,患者经常会出现严重的副作用。此外,双膦酸盐通过引发破骨细胞凋亡来抑制骨质流失,破骨细胞负责清除旧骨,从而使旧骨堆积,并减缓成骨细胞生成新骨的活动,进而影响骨质量。作为一种替代方法,有益骨骼的生活方式,包括摄入钙和维生素D、锻炼、戒烟以及减少酒精摄入,可能会减少骨质流失。本病例报告描述了一名绝经后女性通过饮食和锻炼等生活方式改变,在两年内增加了骨矿物质密度,且无负面副作用。