Levine S, Weiser P, Gillen J
Am Rev Respir Dis. 1986 Mar;133(3):400-6. doi: 10.1164/arrd.1986.133.3.400.
To evaluate the role of ventilatory muscle endurance training (VMET) in the rehabilitation of outpatients with chronic obstructive pulmonary disease, we carried out a prospective random allocation trial of VMET versus IPPB. Data were obtained from 15 men allocated to VMET and from 17 men assigned to IPPB. The mean age of our experimental cohort was 61 +/- SEM 1 yr, and the FEV1 was 1.2 +/- 0.1 L. Prior to and after 6 wk of daily therapy, the following data were obtained on each subject: (1) vital statistics, (2) standard pulmonary function tests, (3) activities of daily living (ADL), (4) maximal sustainable ventilatory capacity (MSVC), (5) psychologic status (PS), and (6) exercise tolerance (ET). Prior to therapy, the VMET and IPPB groups showed no significant differences with respect to these parameters. After therapy, VMET subjects exhibited a greater increase (p less than 0.05) in MSVC than did IPPB subjects. However, VMET and IPPB groups did not differ with respect to improvements noted in ADL, PS, and ET. These results from our controlled study raise the possibility that some aspect of the experimental protocol, other than VMET, accounted for the improvements noted in ADL, PS, and ET.
为评估通气肌耐力训练（VMET）在慢性阻塞性肺疾病门诊患者康复中的作用，我们开展了一项VMET与间歇性正压通气（IPPB）对比的前瞻性随机分配试验。数据来自15名分配至VMET组的男性和17名分配至IPPB组的男性。我们实验队列的平均年龄为61±标准误1岁，第一秒用力呼气容积（FEV1）为1.2±0.1升。在每日治疗6周之前和之后，获取了每位受试者的以下数据：（1）生命统计数据，（2）标准肺功能测试，（3）日常生活活动能力（ADL），（4）最大可持续通气能力（MSVC），（5）心理状态（PS），以及（6）运动耐量（ET）。治疗前，VMET组和IPPB组在这些参数方面无显著差异。治疗后，VMET组受试者的MSVC增加幅度大于IPPB组受试者（p<0.05）。然而，VMET组和IPPB组在ADL、PS和ET的改善方面并无差异。我们这项对照研究的结果表明，除VMET外，实验方案的某些方面可能是ADL、PS和ET出现改善的原因。
