Laguna-Muñoz David, Jiménez-Peinado Ana, Jaén-Moreno María José, Camacho-Rodríguez Cristina, Del Pozo Gloria Isabel, Vieta Eduard, Caballero-Villarraso Javier, Khan Muhammad Ijlal, Rico-Villademoros Fernando, Sarramea Fernando
Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Córdoba, Spain.
Reina Sofia University Hospital, Córdoba, Spain.
Mol Psychiatry. 2025 Feb;30(2):777-785. doi: 10.1038/s41380-024-02793-1. Epub 2024 Nov 14.
People with bipolar disorder (BD) have an increased risk of premature mortality and the respiratory mortality rate is higher than those of the general population. To date, however, the evidence on respiratory disease in this population has not been meta-analyzed. We systematically review and meta-analyze the frequency of respiratory diseases in patients with BD and to compare prevalence and odds ratio (OR) with the general population. The systematic literature search was conducted in Pubmed, PsycINFO, Scielo and Scopus, with snowball search of reference and citation lists. Inclusion criteria were studies reporting diagnoses of respiratory diseases (asthma, chronic obstructive pulmonary disease (COPD), pneumonia, lung cancer and tuberculosis) in people with BD according to operationalized criteria and where possible, control group. Of the 2158 articles screened, 20 including 962,352 people with BD and 37,340,405 control group, met the inclusion criteria. In people with BD, the prevalence of COPD was 9.14% (95%CI: 6.61-12.5%), asthma 6.4% (95%CI: 4.56-8.91%), pneumonia 2.78% (95%CI: 2.51-3.08%) and lung cancer 0.44% (95%CI:0.23-0.84%). Compared to the general population, people with BD had significantly higher rates of COPD (OR: 1.73; 95% CI: 1.40-2.14), showing an increased rate in younger and female patients; asthma (OR: 1.91, 95% CI: 1.25-2.94), with a greater rate in younger patients; and pneumonia (OR: 2.82, 95% CI: 1.33-5.99). In the first meta-analysis on the topic, BD was associated with an increased risk of respiratory illness versus the general population. In COPD and asthma, young people and women are at particular risk. Prevention programs are urgently needed.
双相情感障碍（BD）患者过早死亡的风险增加，其呼吸系统死亡率高于普通人群。然而，迄今为止，关于该人群呼吸系统疾病的证据尚未进行荟萃分析。我们系统地回顾并荟萃分析了BD患者呼吸系统疾病的发生频率，并将其患病率和比值比（OR）与普通人群进行比较。在PubMed、PsycINFO、Scielo和Scopus数据库中进行了系统的文献检索，并通过对参考文献和引用列表进行滚雪球式检索。纳入标准为根据可操作标准报告BD患者呼吸系统疾病（哮喘、慢性阻塞性肺疾病（COPD）、肺炎、肺癌和肺结核）诊断的研究，如有可能，还需有对照组。在筛选的2158篇文章中，有20篇符合纳入标准，共纳入962352例BD患者和37340405例对照组。在BD患者中，COPD的患病率为9.14%（95%CI：6.61 - 12.5%），哮喘为6.4%（95%CI：4.56 - 8.91%），肺炎为2.78%（95%CI：2.51 - 3.08%），肺癌为0.44%（95%CI：0.23 - 0.84%）。与普通人群相比，BD患者的COPD发生率显著更高（OR：1.73；95%CI：1.40 - 2.14），在年轻患者和女性患者中发生率更高；哮喘（OR：1.91，95%CI：1.25 - 2.94），在年轻患者中发生率更高；肺炎（OR：2.82，95%CI：1.33 - 5.99）。在该主题的首次荟萃分析中，BD与普通人群相比呼吸系统疾病风险增加相关。在COPD和哮喘方面，年轻人和女性尤其危险。迫切需要预防项目。
