Lupton G P, McMarlin S L
Arch Dermatol. 1986 Mar;122(3):286-9. doi: 10.1001/archderm.122.3.286.
Microcystic adnexal carcinoma is a recently described neoplasm characterized by a locally aggressive growth pattern. The tumor usually affects the upper lip of middle-aged women, but occurs in other facial areas and in men. Histologically, a distinctive combination of keratin-filled cysts, islands and strands of basaloid and squamous cells, and ducts and glandlike structures is seen. A dense, hyalinized stroma is also a feature as well as frequent perineural invasion by tumor cells. While microcystic adnexal carcinoma is deeply infiltrating in its growth, metastasis has not been reported. However, recurrences with extensive local tumor spread are often observed. We describe a middle-aged man who initially had a lesion of microcystic adnexal carcinoma excised 30 years prior to definitive treatment for a recurrence at the original site. To our knowledge, this is the longest follow-up of a patient with microcystic adnexal carcinoma and confirms its locally infiltrating, indolent biologic behavior.
微囊性附属器癌是一种最近才被描述的肿瘤，其特征为局部侵袭性生长模式。该肿瘤通常累及中年女性的上唇，但也可发生于其他面部区域以及男性。在组织学上，可见充满角蛋白的囊肿、基底样和鳞状细胞岛及条索、导管和腺样结构的独特组合。致密、玻璃样变的间质也是其特征之一，肿瘤细胞常沿神经周围浸润。虽然微囊性附属器癌生长时呈深部浸润，但尚未见转移的报道。然而，常观察到局部肿瘤广泛播散的复发情况。我们描述了一名中年男性，其最初患有微囊性附属器癌病变，在对原部位复发进行确定性治疗前30年已切除该病变。据我们所知，这是对微囊性附属器癌患者最长时间的随访，证实了其局部浸润、生长缓慢的生物学行为。
