Mandlik Rubina, Deshpande Swapna, Khadilkar Anuradha
Growth and Pediatric Endocrinology, Hirabai Cowasji Jehangir Medical Research Institute, Pune, IND.
Health Sciences, Tampere University, Tampere, FIN.
Cureus. 2024 Oct 15;16(10):e71513. doi: 10.7759/cureus.71513. eCollection 2024 Oct.
An understanding of the influence of family relationship on vitamin D concentrations could be useful in designing community-based strategies to improve vitamin D status. Hence, the aim of this study was to explore if family relationship had an impact on total serum 25-hydroxyvitamin D (25OHD) concentrations of individuals living in Pune, India.
This cross-sectional study included 104 families. Data collected included anthropometry (height and weight), body composition (bioelectric impedance), sunlight exposure (validated questionnaire), and blood samples for estimation of serum 25OHD and 25OHD by liquid chromatography-tandem mass spectrometry (LC-MS/MS) method. Total serum 25OHD was computed as the sum of the serum 25OHD and 25OHD concentrations. Linear mixed model analysis was employed to assess the impact of family on serum 25OHD and total 25OHD concentrations. The strength of the family-level component was assessed by calculating the intra-family correlation for each model separately for children and adults.
More than half (63%) of the participants of the participants (235 adults, 118 children) had poor daily sunlight exposure (< 30 minutes). Around one-third, both adults and children, were found to be vitamin D deficient. Intra-family correlation was found to be higher in children than in adults for serum 25OHD (0.6 vs 0.4) and total serum 25OHD (0.5 vs 0.1) concentrations.
Our findings indicate that the likelihood of having similar vitamin D concentrations is higher among children as compared to adults in a family. This suggests a role played by genetic factors or possibly shared habits among children in a family, thus resulting in stronger correlations. This can facilitate the adoption of early preventive measures for treatment or prevention of vitamin D deficiency, even if one child among siblings is vitamin D insufficient.
了解家庭关系对维生素D浓度的影响，可能有助于设计基于社区的策略来改善维生素D状况。因此，本研究的目的是探讨家庭关系是否会对印度浦那居民的血清总25-羟基维生素D（25OHD）浓度产生影响。
这项横断面研究纳入了104个家庭。收集的数据包括人体测量学指标（身高和体重）、身体成分（生物电阻抗）、阳光暴露情况（经过验证的问卷），以及用于通过液相色谱-串联质谱法（LC-MS/MS）测定血清25OHD和25OHD的血样。血清总25OHD通过血清25OHD和25OHD浓度之和来计算。采用线性混合模型分析来评估家庭对血清25OHD和总25OHD浓度的影响。通过分别计算儿童和成人每个模型的家庭内相关性，来评估家庭层面因素的强度。
超过一半（63%）的参与者（235名成年人，118名儿童）每日阳光暴露不足（<30分钟）。大约三分之一的成年人和儿童被发现维生素D缺乏。儿童血清25OHD（0.6对0.4）和血清总25OHD（0.5对0.1）浓度的家庭内相关性高于成年人。
我们的研究结果表明，在一个家庭中，儿童之间维生素D浓度相似的可能性高于成年人。这表明遗传因素或家庭中儿童可能共有的习惯发挥了作用，从而导致更强的相关性。这有助于采取早期预防措施来治疗或预防维生素D缺乏，即使兄弟姐妹中的一个儿童维生素D不足。
