Goyal Anjana, Kruthiventi Hemalata
Biochemistry, Manav Rachna Dental College, Manav Rachna International Institute of Research and Studies, Faridabad, IND.
Cureus. 2024 Oct 14;16(10):e71488. doi: 10.7759/cureus.71488. eCollection 2024 Oct.
In recent decades, there has been a significant increase in the number of diseases, with endocrine diseases, such as polycystic ovarian syndrome (PCOS), showing a notable rise. Women with PCOS have a higher risk of depression and stress which can affect the academic performance of the students. Hence, this study aims to compare salivary oxidative stress biomarkers, mental stress levels, body mass index (BMI), and waist-hip ratio (WHR) in students with and without PCOS, and examine the impact of these factors on academic performance.
Female students (n=71) with self-reported PCOS (n=36) were compared to those without PCOS (n=35). Perceived and academic stress were assessed using validated scales, while BMI and WHR were measured through physical examination. Academic performance was self-reported and validated by follow-up interviews. Salivary MDA, a biomarker for oxidative stress, was measured using an enzyme-linked immunoassay (ELISA) test.
The analysis revealed that female students with PCOS exhibited higher MDA (ng/ml) levels (0.71±0.13 vs. 0.41±0.14), perceived stress (28.42±4.75 vs. 22.0±6.62), BMI (26.74±6.28 vs. 23.87±4.81), and academic stress (91.03±31.52 vs. 66.86±30.98) compared to those without PCOS. In participants with PCOS, BMI showed a weak positive correlation with academic stress (r=0.312), while the Perceived Stress Score (PSS) and MDA levels showed a strong positive correlation with academic stress (r=0.709 and 0.850, respectively). Academic performance was weakly positively correlated with perceived stress score (r=0.384).
When individual factors (BMI, perceived stress, MDA levels) were compared, positive significance was observed in both PCOS and non-PCOS groups. Findings suggested that female students diagnosed with PCOS experience elevated levels of perceived stress, salivary MDA, and BMI, potentially impacting their academic performance.
近几十年来，疾病数量显著增加，内分泌疾病如多囊卵巢综合征（PCOS）的发病率明显上升。患有PCOS的女性患抑郁症和压力的风险更高，这可能会影响学生的学业成绩。因此，本研究旨在比较患有和未患有PCOS的学生的唾液氧化应激生物标志物、心理压力水平、体重指数（BMI）和腰臀比（WHR），并研究这些因素对学业成绩的影响。
将自我报告患有PCOS的女学生（n = 36）与未患有PCOS的女学生（n = 35）进行比较。使用经过验证的量表评估感知压力和学业压力，通过体格检查测量BMI和WHR。学业成绩通过自我报告并经后续访谈验证。使用酶联免疫吸附测定（ELISA）测试测量唾液丙二醛（MDA），这是一种氧化应激生物标志物。
分析显示，与未患有PCOS的学生相比，患有PCOS的女学生的MDA（ng/ml）水平更高（0.71±0.13对0.41±0.14）、感知压力更高（28.42±4.75对22.0±6.62）、BMI更高（26.74±6.28对23.87±4.81）以及学业压力更高（91.03±31.52对66.86±30.98）。在患有PCOS的参与者中，BMI与学业压力呈弱正相关（r = 0.312），而感知压力评分（PSS）和MDA水平与学业压力呈强正相关（分别为r = 0.709和0.850）。学业成绩与感知压力评分呈弱正相关（r = 0.384）。
当比较个体因素（BMI、感知压力、MDA水平）时，在PCOS组和非PCOS组中均观察到显著差异。研究结果表明，被诊断患有PCOS的女学生感知压力、唾液MDA和BMI水平升高，可能会影响她们的学业成绩。
