Xin Xiaoqin, Zhang Qi, Xu Jing, Huang Jungao
Department of Clinical Laboratory, Ganzhou People's Hospital, Ganzhou, Jiangxi, People's Republic of China.
Department of Obstetrics and Gynecology, Ganzhou Maternal and Child Health Hospital, Ganzhou, Jiangxi, People's Republic of China.
Int J Womens Health. 2025 Jan 8;17:33-42. doi: 10.2147/IJWH.S484872. eCollection 2025.
Few studies have evaluated the correlation between serum uric acid (SUA) levels and the prevalence of female infertility in the general population, and the effect of magnesium intake on this correlation has not been investigated.
All participants aged 18-45 years at baseline were enrolled from the National Health and Nutritional Examination Surveys (NHANES) 2013-2018. The continuous variable of SUA was divided into quartile (Q1: ≤3.7 mg/dL, Q2: 3.7-4.4 mg/dL, Q3: 4.4-5.1 mg/dL, Q4: ≥5.1 mg/dL). Multivariable logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI). Dietary magnesium was divided into two groups based on the median number of participants (low magnesium intake, <243 mg/day; high magnesium intake, ≥243 mg/day).
A total of 3185 female participants were included in the final analysis, 10.58% of whom were infertile. In the full adjustment model, SUA was positively associated with female infertility (OR=1.13, 95% CI: 1.01-1.27). Compared to the lowest quartile (Q1), female participants with the highest SUA levels (Q4) had an increased risk of infertility by 62% (OR=1.62, 95% CI: 1.1-2.4). Moreover, we found an interactive effect of magnesium intake on the association between SUA and infertility in adjusted models (interaction likelihood ratio test: P=0.029), implying that high magnesium intake may ameliorate the association between SUA and female infertility.
This study is the first to report an interactive effect of dietary magnesium intake on the relationship between SUA and female infertility.
很少有研究评估普通人群中血清尿酸（SUA）水平与女性不孕症患病率之间的相关性，且尚未研究镁摄入量对这种相关性的影响。
所有基线年龄在18至45岁之间的参与者均来自2013 - 2018年国家健康与营养检查调查（NHANES）。SUA的连续变量被分为四分位数（Q1：≤3.7mg/dL，Q2：3.7 - 4.4mg/dL，Q3：4.4 - 5.1mg/dL，Q4：≥5.1mg/dL）。采用多变量逻辑回归来估计比值比（OR）和95%置信区间（CI）。根据参与者数量的中位数将膳食镁分为两组（低镁摄入量，<243mg/天；高镁摄入量，≥243mg/天）。
最终分析共纳入3185名女性参与者，其中10.58%为不孕症患者。在完全调整模型中，SUA与女性不孕症呈正相关（OR = 1.13，95%CI：1.01 - 1.27）。与最低四分位数（Q1）相比，SUA水平最高（Q4）的女性参与者不孕风险增加了62%（OR = 1.62，95%CI：1.1 - 2.4）。此外，我们发现在调整模型中镁摄入量对SUA与不孕症之间的关联存在交互作用（交互似然比检验：P = 0.029），这意味着高镁摄入量可能会改善SUA与女性不孕症之间的关联。
本研究首次报道了膳食镁摄入量对SUA与女性不孕症关系的交互作用。
