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丙酸通过调节结肠调节性T细胞的扩增和再循环减轻腹主动脉瘤

Propionate Alleviates Abdominal Aortic Aneurysm by Modulating Colonic Regulatory T-Cell Expansion and Recirculation.

作者信息

Yang Fen, Xia Ni, Guo Shuang, Zhang Jiyu, Liao Yuhan, Tang Tingting, Nie Shaofang, Zhang Min, Lv Bingjie, Lu Yuzhi, Jiao Jiao, Li Jingyong, Wang Weimin, Hu Desheng, Cheng Xiang

机构信息

Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, and Key Laboratory of Biological Targeted Therapy of the Ministry of Education, Wuhan, China.

Department of Immunology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

出版信息

JACC Basic Transl Sci. 2022 Aug 31;7(9):934-947. doi: 10.1016/j.jacbts.2022.05.001. eCollection 2022 Sep.

DOI:10.1016/j.jacbts.2022.05.001
PMID:36317128
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9617133/
Abstract

Emerging evidence supports that intestinal microbial metabolite short-chain fatty acids (SCFAs) increase the pool of regulatory T cells (Tregs) in the colonic lamina propria (cLP) and protect against nonintestinal inflammatory diseases, such as atherosclerosis and post-infarction myocardial inflammation. However, whether and how SCFAs protect the inflamed aortas of subjects with abdominal aortic aneurysm (AAA) remains unclear. Here, the authors revealed the protective effect of SCFAs on AAA in mice and the expansion of Tregs in the cLP, and propionate exerted Treg-dependent protection against AAA by promoting the recirculation of cLP-Tregs through colonic draining lymph nodes (dLNs) to the inflamed aorta.

摘要

新出现的证据表明，肠道微生物代谢产物短链脂肪酸（SCFAs）可增加结肠固有层（cLP）中调节性T细胞（Tregs）的数量，并预防非肠道炎症性疾病，如动脉粥样硬化和心肌梗死后炎症。然而，SCFAs是否以及如何保护腹主动脉瘤（AAA）患者的发炎主动脉仍不清楚。在此，作者揭示了SCFAs对小鼠AAA的保护作用以及cLP中Tregs的扩增，并且丙酸通过促进cLP-Tregs通过结肠引流淋巴结（dLNs）再循环至发炎的主动脉，发挥了对AAA的Treg依赖性保护作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0764/9617133/b3f7699129d5/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0764/9617133/7b966acb6e72/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0764/9617133/6b0dd43ac626/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0764/9617133/9afe2828bdf2/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0764/9617133/7ecb7928d8dc/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0764/9617133/598cd965e56a/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0764/9617133/447776e1f8e9/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0764/9617133/b3f7699129d5/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0764/9617133/7b966acb6e72/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0764/9617133/6b0dd43ac626/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0764/9617133/9afe2828bdf2/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0764/9617133/7ecb7928d8dc/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0764/9617133/598cd965e56a/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0764/9617133/447776e1f8e9/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0764/9617133/b3f7699129d5/gr6.jpg

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