Shen Ying, Zhang Wanting, Jin Huyi, Guo Fanjia, Jin Mingjuan, Chen Guangdi
Department of Child Health Care, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.
Department of Public Health, Zhejiang University School of Medicine, Hangzhou, China.
Pediatr Res. 2024 Nov 16. doi: 10.1038/s41390-024-03729-9.
Essential metals may play roles in neurodevelopment. The aim was to evaluate the associations of magnesium (Mg), iron (Fe), copper (Cu), and zinc (Zn) levels with neurodevelopment among preschool children.
The medical records of eligible children enrolled between January 2019 and July 2022 were retrospectively reviewed for required information. The quantitative measurement of metals was conducted using atomic absorption spectroscopy, while screening of neurodevelopment was performed using the Ages and Stages Questionnaire. Modified Poisson regression and Bayesian kernel machine regression (BKMR) analyses were used to evaluate the prevalence ratio (PR) of their independent and joint associations.
662 (14.8%) children were found to have possible neurodevelopmental delays. Modified Poisson regression showed that Mg, Cu, and Zn levels were independently and negatively associated with the risk of neurodevelopmental delay. The PRs (95% CIs) for per log increment of the above metals were 0.35 (0.19-0.62), 0.57 (0.42-0.77), and 0.63 (0.42-0.96). These negative associations were more pronounced in the gross motor and personal-social domains while considering the concrete five domains. BKMR showed a negative association of metal mixture with the risk of neurodevelopmental delay.
Mg, Cu, and Zn were inversely associated with neurodevelopmental delay. Sufficient essential metal levels are important for neurodevelopment.
Essential metals play a key role in neurodevelopment. The association of essential metal mixture with neurodevelopment is relatively scarce. Preschool children with possible neurodevelopmental delay are found to have lower Mg, Cu, and Zn levels than their counterparts. Single Mg, Cu, Zn levels, and elevated essential metal mixture are negatively associated with the risk of possible neurodevelopmental delay.
必需金属可能在神经发育中发挥作用。目的是评估镁（Mg）、铁（Fe）、铜（Cu）和锌（Zn）水平与学龄前儿童神经发育之间的关联。
回顾性查阅2019年1月至2022年7月期间符合条件儿童的病历以获取所需信息。使用原子吸收光谱法对金属进行定量测量，同时使用年龄与发育进程问卷对神经发育进行筛查。采用修正泊松回归和贝叶斯核机器回归（BKMR）分析来评估其独立和联合关联的患病率比（PR）。
发现662名（14.8%）儿童可能存在神经发育迟缓。修正泊松回归显示，Mg、Cu和Zn水平与神经发育迟缓风险呈独立负相关。上述金属每增加一个对数单位的PR（95%CI）分别为0.35（0.19 - 0.62）、0.57（0.42 - 0.77）和0.63（0.42 - 0.96）。在考虑具体的五个领域时，这些负相关在大运动和个人 - 社会领域更为明显。BKMR显示金属混合物与神经发育迟缓风险呈负相关。
Mg、Cu和Zn与神经发育迟缓呈负相关。充足的必需金属水平对神经发育很重要。
必需金属在神经发育中起关键作用。必需金属混合物与神经发育之间的关联相对较少。发现可能存在神经发育迟缓的学龄前儿童的Mg、Cu和Zn水平低于同龄人。单一的Mg、Cu、Zn水平以及升高的必需金属混合物与可能的神经发育迟缓风险呈负相关。
