细胞黏附的热力学。II. 自由移动的排斥物。
Thermodynamics of cell adhesion. II. Freely mobile repellers.
作者信息
Torney D C, Dembo M, Bell G I
出版信息
Biophys J. 1986 Feb;49(2):501-7. doi: 10.1016/S0006-3495(86)83660-8.
Abstract
The equilibrium adhesion of a cell or vesicle to a substrate is analyzed in a theoretical model in which two types of mobile molecules in the cell membrane are of interest: receptors that can form bonds with fixed ligands in the substrate and repellers that repel the substrate. If the repulsion between the repeller molecule and substrate is greater than kT, there is substantial redistribution of the repellers from the contact area. Coexisting equilibrium states are observed having comparable free energies (a) with unstretched bonds and repeller redistribution and (b) with stretched bonds and partial redistribution.
摘要
在一个理论模型中分析了细胞或囊泡与底物的平衡粘附，该模型关注细胞膜中的两种移动分子：可与底物中固定配体形成键的受体和排斥底物的排斥分子。如果排斥分子与底物之间的排斥力大于kT，则排斥分子会从接触区域大量重新分布。观察到共存的平衡状态具有相当的自由能：（a）未拉伸键和排斥分子重新分布的状态，以及（b）拉伸键和部分重新分布的状态。
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2
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3
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4
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