Zhang Jia-Xin, Li Qin-Lan, Wang Xiao-Yan, Zhang Cheng-Chang, Chen Shu-Ting, Liu Xiao-Hang, Dong Xin-Yi, Zhao Hu, Huang Dong-Hui
Institute of Reproduction Health Research, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Reproductive Center, Qingdao Women and Children's Hospital Affiliated to Qingdao University, Qingdao, 266034, China.
Curr Med Sci. 2024 Dec;44(6):1312-1324. doi: 10.1007/s11596-024-2931-x. Epub 2024 Nov 18.
To investigate the associations of the gut microbiota with reproductive system diseases, including female infertility, male infertility, polycystic ovary syndrome (PCOS), primary ovarian failure, endometriosis, uterine fibroids, uterine polyps, sexual dysfunction, orchitis, and epididymitis.
A two-sample bidirectional Mendelian randomization (MR) analysis was performed to evaluate the potential causal relationship between the composition of gut microbiota and infertility, along with associated diseases.
Sixteen strong causal associations between gut microbes and reproductive system diseases were identified. Sixty-one causal associations between gut microbes and reproductive system diseases were determined. The genus Eubacterium hallii was a protective factor against premature ovarian failure and a pathogenic factor of endometriosis. The genus Erysipelatoclostridium was the pathogenic factor of many diseases, such as PCOS, endometriosis, epididymitis, and orchitis. The genus Intestinibacter is a pathogenic factor of male infertility and sexual dysfunction. The family Clostridiaceae 1 was a protective factor against uterine polyps and a pathogenic factor of orchitis and epididymitis. The results of reverse causal association analysis revealed that endometriosis, orchitis, and epididymitis all led to a decrease in the abundance of bifidobacteria and that female infertility-related diseases had a greater impact on gut microbes than male infertility-related diseases did.
The findings from the MR analysis indicate that there is a bidirectional causal relationship between the gut microbiota and infertility as well as associated ailments. Compared with ovarian diseases, uterine diseases are more likely to lead to changes in women's gut microbiota. The findings of this research offer valuable perspectives on the mechanism and clinical investigation of reproductive system diseases caused by microorganisms.
探讨肠道微生物群与生殖系统疾病的关联，包括女性不孕症、男性不孕症、多囊卵巢综合征（PCOS）、原发性卵巢功能衰竭、子宫内膜异位症、子宫肌瘤、子宫息肉、性功能障碍、睾丸炎和附睾炎。
进行两样本双向孟德尔随机化（MR）分析，以评估肠道微生物群组成与不孕症及相关疾病之间的潜在因果关系。
确定了肠道微生物与生殖系统疾病之间的16种强因果关联。确定了肠道微生物与生殖系统疾病之间的61种因果关联。哈氏真杆菌属是预防卵巢早衰的保护因素，也是子宫内膜异位症的致病因素。梭状芽孢杆菌属是多种疾病的致病因素，如PCOS、子宫内膜异位症、附睾炎和睾丸炎。肠杆菌属是男性不育和性功能障碍的致病因素。毛螺菌科1是预防子宫息肉的保护因素，也是睾丸炎和附睾炎的致病因素。反向因果关联分析结果显示，子宫内膜异位症、睾丸炎和附睾炎均导致双歧杆菌丰度降低，且女性不孕症相关疾病对肠道微生物的影响大于男性不孕症相关疾病。
MR分析结果表明，肠道微生物群与不孕症及相关疾病之间存在双向因果关系。与卵巢疾病相比，子宫疾病更易导致女性肠道微生物群的变化。本研究结果为微生物引起的生殖系统疾病的机制和临床研究提供了有价值的观点。
