Jihwaprani Muhammad Candragupta, Sula Idris, Coha Daniel, Alhebshi Ahmed, Alsamal Mohamad, Hassaneen Ahmad M, Alreshidi Mateq Ali, Saquib Nazmus
Department of Pediatrics, Sidra Medicine, Doha, Qatar.
College of Medicine, Sulaiman Al Rajhi University, Al Bukaryiah, Saudi Arabia *Email:
Qatar Med J. 2024 Nov 11;2024(4):62. doi: 10.5339/qmj.2024.62. eCollection 2024.
Neonatal sepsis (NS) is a major healthcare burden in Gulf Cooperation Council (GCC) countries, with a prevalence higher than the global average. Microbial drug resistance has major implications for mortality and morbidity from NS.
To synthesize data regarding the patterns of causative bacteria of NS in the GCC and their antimicrobial susceptibility profiles.
Following the exploration of four electronic databases, i.e., EBSCOhost, ProQuest, PubMed/MEDLINE, and ScienceDirect, eligible studies were identified (i.e., published between 2013 and 2023 and reported bacterial profile and/or antimicrobial susceptibility patterns). The outcomes included the pooled prevalence of bacteria and their susceptibility patterns. Proportion meta-analysis was performed for each outcome of interest.
Fifteen studies were eligible (total positive cases = 2,473). Coagulase-negative (CoNS) (28.1%) were the most common gram-positive causative pathogen, followed by group B (GBS) (16.2%) and (9.9%); for gram-negative, (12.7%) and species (11.4%) were most common. The susceptibility rates of these bacteria to first-line antibiotics were high; gram-positive bacteria had the highest susceptibility to ampicillin (72.8-98%), and gram-negative bacteria was most susceptible to amikacin (94.6-98%). Additionally, both gram-positive (67-77%) and negative (87-93%) bacteria exhibited high susceptibility to gentamicin.
The most common pathogens among NS patients were gram-positive. The pathogens, irrespective of stain test, were susceptible to the current antibiotic therapy. We recommend the judicious use of empirical antibiotic therapy to prevent the growing risk of antimicrobial resistance.
新生儿败血症（NS）是海湾合作委员会（GCC）国家主要的医疗负担，其患病率高于全球平均水平。微生物耐药性对新生儿败血症的死亡率和发病率有重大影响。
综合有关海湾合作委员会地区新生儿败血症致病菌模式及其抗菌药物敏感性谱的数据。
在检索了四个电子数据库，即EBSCOhost、ProQuest、PubMed/MEDLINE和ScienceDirect之后，确定了符合条件的研究（即2013年至2023年期间发表并报告了细菌谱和/或抗菌药物敏感性模式的研究）。结果包括细菌的合并患病率及其敏感性模式。对每个感兴趣的结果进行比例荟萃分析。
15项研究符合条件（总阳性病例数=2473）。凝固酶阴性葡萄球菌（CoNS）（28.1%）是最常见的革兰氏阳性致病菌，其次是B组链球菌（GBS）（16.2%）和金黄色葡萄球菌（9.9%）；革兰氏阴性菌中，大肠埃希菌（12.7%）和肺炎克雷伯菌属（11.4%）最为常见。这些细菌对一线抗生素的敏感率较高；革兰氏阳性菌对氨苄西林的敏感性最高（72.8 - 98%），革兰氏阴性菌对阿米卡星最敏感（94.6 - 98%）。此外，革兰氏阳性菌（67 - 77%）和革兰氏阴性菌（87 - 93%）对庆大霉素也表现出较高的敏感性。
新生儿败血症患者中最常见的病原体是革兰氏阳性菌。无论染色试验结果如何，这些病原体对目前的抗生素治疗均敏感。我们建议谨慎使用经验性抗生素治疗，以防止抗菌药物耐药性风险的增加。
