Han Changliang, Zhai Cuili, Li Ailing, Ma Yongzhi, Hallajzadeh Jamal
Lishui University, Lishui, Zhejiang, China.
College of Chinese Martial Arts, Beijing Sport University, Beijing, China.
Front Cardiovasc Med. 2024 Nov 1;11:1432468. doi: 10.3389/fcvm.2024.1432468. eCollection 2024.
Myocardial infarction (MI), a widespread cardiovascular issue, mainly occurs due to blood clot formation in the coronary arteries, which reduces blood flow to the heart muscle and leads to cell death. Incorporating exercise into a lifestyle can significantly benefit recovery and reduce the risk of future cardiac events for MI patients. Non-coding RNAs (ncRNAs) play various roles in the effects of exercise on myocardial infarction (MI). ncRNAs regulate gene expression, influence cardiac remodeling, angiogenesis, inflammation, oxidative stress, apoptosis, cardioprotection, and cardiac electrophysiology. The expression of specific ncRNAs is altered by exercise, leading to beneficial changes in heart structure, function, and recovery after MI. These ncRNAs modulate molecular pathways that contribute to improved cardiac health, including reducing inflammation, enhancing angiogenesis, promoting cell survival, and mitigating oxidative stress. Furthermore, they are involved in regulating changes in cardiac remodeling, such as hypertrophy and fibrosis, and can influence the electrical properties of the heart, thereby decreasing the risk of arrhythmias. Knowledge on MI has entered a new phase, with investigations of ncRNAs in physical exercise yielding invaluable insights into the impact of this therapeutic modality. This review compiled research on ncRNAs in MI, with an emphasis on their applicability to physical activity.
心肌梗死（MI）是一种广泛存在的心血管疾病，主要是由于冠状动脉中形成血栓，减少了流向心肌的血液，导致细胞死亡。将运动纳入生活方式可以显著有益于心肌梗死患者的康复，并降低未来发生心脏事件的风险。非编码RNA（ncRNAs）在运动对心肌梗死（MI）的影响中发挥着多种作用。ncRNAs调节基因表达，影响心脏重塑、血管生成、炎症、氧化应激、细胞凋亡、心脏保护和心脏电生理。特定ncRNAs的表达会因运动而改变，从而导致心肌梗死后心脏结构、功能和恢复的有益变化。这些ncRNAs调节有助于改善心脏健康的分子途径，包括减轻炎症、增强血管生成、促进细胞存活和减轻氧化应激。此外，它们还参与调节心脏重塑的变化，如肥大和纤维化，并可影响心脏的电特性，从而降低心律失常的风险。关于心肌梗死的知识已进入一个新阶段，对ncRNAs在体育锻炼中的研究为这种治疗方式的影响提供了宝贵的见解。本综述汇编了关于心肌梗死中ncRNAs的研究，重点是它们在体育活动中的适用性。
