Chin Anique Vanessa, Thompson Tamara, Denton Cobrini S, Lindo John F
Department of Microbiology, The University of the West Indies, Kingston 7, Jamaica.
Department of Medicine, The University of the West Indies, Kingston 7, Jamaica.
J Trop Med. 2024 Nov 9;2024:4578159. doi: 10.1155/2024/4578159. eCollection 2024.
is a soil-transmitted helminth which is distributed predominately throughout tropical and subtropical regions and is considered a neglected tropical disease. Due to low larval output, traditional microscopic methods lack sensitivity, especially in areas of low endemicity. Serological assays present an opportunity to study the epidemiology of in areas of low endemicity such as Jamaica. The current study evaluated the seroprevalence of in a selected subpopulation in Jamaica. An analysis was conducted on 311 archived serum samples previously submitted for investigating viral infections during a fever epidemic between 2014 and 2015. Randomly selected, anonymized sera were tested for the presence of . IgG antibodies using the AccuDiag IgG ELISA Kit. Data including age, sex, clinical diagnosis, and the geographic location of sample submission were recorded to delineate trends in demographic variables. The seropositivity rate of was 15.43%. The rate among females and males was 16.45% and 14.47%, respectively ( = 0.2339, =0.629). The highest rate was found in middle adulthood (31-50 years) (26.53%; 13/49). The seroprevalence of was significantly highest in a rural Regional Health Authority (33.33%; 14/42) and least within an urban Health Authority (9.71%; 17/175). Exposure to appears to be highest in the rural Regional Health Authorities with an island-wide exposure rate of 15.43%. The rapid ELISA testing method for the detection of IgG antibodies to used in this study may be useful as part of a combined approach to elucidate the epidemiology of this soil-transmitted parasite in Jamaica.
是一种土源性蠕虫，主要分布在热带和亚热带地区，被视为一种被忽视的热带病。由于幼虫产出量低，传统显微镜检查方法缺乏敏感性，尤其是在低流行地区。血清学检测为研究牙买加等低流行地区的流行病学提供了机会。本研究评估了牙买加特定亚人群中的血清流行率。对2014年至2015年发热疫情期间之前提交用于调查病毒感染的311份存档血清样本进行了分析。随机选择匿名血清，使用AccuDiag IgG ELISA试剂盒检测是否存在IgG抗体。记录包括年龄、性别、临床诊断和样本提交地理位置的数据，以描绘人口统计学变量的趋势。的血清阳性率为15.43%。女性和男性的阳性率分别为16.45%和14.47%（P = 0.2339，χ² = 0.629）。最高发生率出现在中年（31 - 50岁）（26.53%；13/49）。在农村地区卫生局，的血清流行率显著最高（33.33%；14/42），而在城市卫生局中最低（9.71%；17/175）。在农村地区卫生局，接触的情况似乎最为普遍，全岛接触率为15.43%。本研究中用于检测IgG抗体的快速ELISA检测方法，作为阐明牙买加这种土源性寄生虫流行病学的综合方法的一部分，可能会很有用。
