微流控技术在mRNA疫苗研发中的应用：综述
Applications of microfluidics in mRNA vaccine development: A review.
作者信息
Fardoost Ali, Karimi Koosha, Govindaraju Harshitha, Jamali Pegah, Javanmard Mehdi
机构信息
Department of Electrical and Computer Engineering, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA.
出版信息
Biomicrofluidics. 2024 Nov 14;18(6):061502. doi: 10.1063/5.0228447. eCollection 2024 Dec.
The transformative potential of microfluidics in the development of mRNA vaccines is explored in this review, highlighting its pivotal role in enhancing easy-to-use functionality, efficacy, and production efficiency. Moreover, we examine the innovative applications of microfluidics in biomedical research, including its contribution to the rapid and cost-effective synthesis of lipid nanoparticles for mRNA delivery and delve into the advantages of mRNA vaccines, such as targeted delivery and controlled expression. Furthermore, it outlines the future prospects of microfluidic devices, their cutting-edge examples in both research and industry, and the potential to revolutionize vaccine formulation and production. The integration of microfluidics with mRNA vaccine development represents a significant advancement in public health and disease prevention strategies.
本综述探讨了微流控技术在mRNA疫苗开发中的变革潜力，强调了其在增强易用性功能、效力和生产效率方面的关键作用。此外，我们研究了微流控技术在生物医学研究中的创新应用，包括其对用于mRNA递送的脂质纳米颗粒的快速且经济高效合成的贡献，并深入探讨了mRNA疫苗的优势，如靶向递送和可控表达。此外，它概述了微流控设备的未来前景、它们在研究和工业中的前沿实例，以及革新疫苗配方和生产的潜力。微流控技术与mRNA疫苗开发的整合代表了公共卫生和疾病预防策略的重大进步。
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