Ning Qiuping, Zhang Zheng, Ren Hua, Fan Tiebing, Li Chunzhi
Qiuping Ning, Department of Radiology, Kulun Banner Mongolian Medicine Hospital, Tongliao City, Inner Mongolia 028200, China. Department of Radiology, China Academy of Chinese Medical Sciences, Xiyuan Hospital, Beijing 100091, China.
Zheng Zhang, Department of Radiology, Kulun Banner Mongolian Medicine Hospital, Tongliao City, Inner Mongolia 028200, China.
Pak J Med Sci. 2024 Nov;40(10):2410-2415. doi: 10.12669/pjms.40.10.8981.
Using magnetic resonance imaging (MRI), we analysed the clinical manifestations of granulomatous lobular mastitis (GLM) before and after treatment with traditional Chinese medicine (TCM).
This was a retrospective study. Clinical manifestations and imaging features of patients with biopsy-proven GLM before and after treatment were retrospectively analysed from April 2021 to April 2023 at Xiyuan Hospital, China Academy of Chinese Medical Sciences.
Among 29 women of childbearing age (mean age, 34.3±3.6 years), Compared to pre-therapy, the number of patients with lumps, ruptures, pain, and menstrual irregularities was significantly reduced (P < 0.05). The Chinese medicine staging demonstrated a transition from bulk to ulcerated (P=0.041). Pre- and post-treatment MRI changes included lesion number, distribution, maximal diameter, time-signal intensity curves (TIC), apparent diffusion coefficients (ADC), and BI-RADS categories 3 and 4a (all P<0.05). Furthermore, substantial changes were seen in chest wall invasion, nipple discharge, increased feeding arteries, and skin edema (all P<0.05).
Combining internal and external Traditional Chinese Medicine (TCM) therapy proved successful for GLM. A reliable assessment of therapy efficacy is provided by MRI examination of lesion changes before and after treatment.
我们使用磁共振成像（MRI）分析了肉芽肿性小叶性乳腺炎（GLM）在中药治疗前后的临床表现。
这是一项回顾性研究。对2021年4月至2023年4月在中国中医科学院西苑医院经活检证实为GLM的患者治疗前后的临床表现和影像学特征进行回顾性分析。
在29名育龄女性（平均年龄34.3±3.6岁）中，与治疗前相比，出现肿块、破溃、疼痛和月经不调的患者数量显著减少（P<0.05）。中医分期显示从肿块期转变为破溃期（P=0.041）。治疗前后MRI的变化包括病灶数量、分布、最大直径、时间-信号强度曲线（TIC）、表观扩散系数（ADC）以及BI-RADS分类3和4a（均P<0.05）。此外，在胸壁侵犯、乳头溢液、供血动脉增多和皮肤水肿方面也有显著变化（均P<0.05）。
中医内外兼治对GLM治疗有效。通过治疗前后病灶变化的MRI检查可提供可靠的疗效评估。
