Jiao Yangchi, Chang Kexin, Jiang Yue, Zhang Juliang
Department of Thyroid, Breast and Vascular Surgery, Xijing Hospital, The Fourth Military Medical University, Xi'an, China.
Ann Transl Med. 2023 Feb 15;11(3):158. doi: 10.21037/atm-22-6473. Epub 2023 Feb 3.
Non-puerperal mastitis (NPM) is a breast disease with poor clinical manifestations, which seriously affects women's health and quality of life. Due to the low incidence rate of the disease and the paucity of related research, there is much misdiagnosis and mis-management of periductal mastitis (PDM) and granulomatous lobular mastitis (GLM). Therefore, understanding the differences between PDM and GLM, in terms of etiology and clinical manifestations, is crucial for patient treatment and prognosis. At the same time, choosing different treatment methods may not achieve the best treatment effect, so the appropriate treatment method can often reduce the patient's pain and reduce the recurrence of the patient's disease.
The PubMed database was searched for articles published from 1 January 1990 to 16 June 2022 using the following search terms: "non-puerperal mastitis", "periductal mastitis", "granulomatous lobular mastitis", "mammary duct ectasia", "idiopathic granulomatous mastitis", "plasma cell mastitis", and "identification". The key findings of the related literatures were analyzed and summarized.
We systematically described the key points in the differential diagnosis, treatment, and prognosis of PDM and GLM. The use of different animal models for research and novel drugs to treat the disease were also described in this paper.
The key points in the differentiation of the two diseases are clearly explained, and the respective treatment options and prognosis are summarized.
非产褥期乳腺炎（NPM）是一种临床表现不佳的乳腺疾病，严重影响女性的健康和生活质量。由于该疾病发病率低且相关研究较少，导管周围乳腺炎（PDM）和肉芽肿性小叶性乳腺炎（GLM）存在诸多误诊和治疗不当的情况。因此，了解PDM和GLM在病因和临床表现方面的差异，对于患者的治疗和预后至关重要。同时，选择不同的治疗方法可能无法达到最佳治疗效果，因此合适的治疗方法通常可以减轻患者的痛苦并降低疾病复发率。
在PubMed数据库中检索1990年1月1日至2022年6月16日发表的文章，使用以下检索词：“非产褥期乳腺炎”、“导管周围乳腺炎”、“肉芽肿性小叶性乳腺炎”、“乳腺导管扩张症”、“特发性肉芽肿性乳腺炎”、“浆细胞性乳腺炎”和“鉴别”。对相关文献的关键发现进行分析和总结。
我们系统地描述了PDM和GLM在鉴别诊断、治疗和预后方面的要点。本文还介绍了使用不同动物模型进行研究以及治疗该疾病的新型药物。
明确解释了两种疾病鉴别的要点，并总结了各自的治疗方案和预后情况。
