Wu Liusheng, Yang Lei, Qian Xinye, Hu Wang, Wang Shuang, Yan Jun
Center of Hepatobiliary Pancreatic Disease, Beijing Tsinghua Changgung Hospital, School of Medicine, Tsinghua University, Beijing 100084, China.
Yong Loo Lin School of Medicine, National University of Singapore, Singapore 19077, Singapore.
J Funct Biomater. 2024 Aug 16;15(8):229. doi: 10.3390/jfb15080229.
With the rapid development of tumor immunotherapy, nanoparticle vaccines have attracted much attention as potential therapeutic strategies. A systematic review and analysis must be carried out to investigate the effect of mannose modification on the immune response to nanoparticles in regulating the tumor microenvironment, as well as to explore its potential clinical application in tumor therapy. Despite the potential advantages of nanoparticle vaccines in immunotherapy, achieving an effective immune response in the tumor microenvironment remains a challenge. Tumor immune escape and the overexpression of immunosuppressive factors limit its clinical application. Therefore, our review explored how to intervene in the immunosuppressive mechanism in the tumor microenvironment through the use of mannan-decorated lipid calcium phosphate nanoparticle vaccines to improve the efficacy of immunotherapy in patients with tumors and to provide new ideas and strategies for the field of tumor therapy.
随着肿瘤免疫疗法的迅速发展，纳米颗粒疫苗作为潜在的治疗策略备受关注。必须进行系统的综述和分析，以研究甘露糖修饰对纳米颗粒免疫反应在调节肿瘤微环境中的作用，以及探索其在肿瘤治疗中的潜在临床应用。尽管纳米颗粒疫苗在免疫疗法中具有潜在优势，但在肿瘤微环境中实现有效的免疫反应仍然是一项挑战。肿瘤免疫逃逸和免疫抑制因子的过度表达限制了其临床应用。因此，我们的综述探讨了如何通过使用甘露聚糖修饰的脂质磷酸钙纳米颗粒疫苗干预肿瘤微环境中的免疫抑制机制，以提高肿瘤患者免疫治疗的疗效，并为肿瘤治疗领域提供新的思路和策略。
