预防听力损失的有效性：饮食消费研究的荟萃分析。
Effectiveness in Preventing Hearing Loss: Meta-Analysis of Dietary Consumption Studies.
作者信息
Gonçalves Laura Faustino, Mary de Paiva Karina, Machado Marcos José, Samelli Alessandra Giannella, Haas Patrícia
机构信息
Health Sciences Center, Federal University of Santa Catarina - UFSC, Florianópolis, Brazil.
Faculty of Medicine, University of São Paulo - USP, Sao Paulo, Brazil.
出版信息
Am J Lifestyle Med. 2024 Feb 10:15598276241231941. doi: 10.1177/15598276241231941.
OBJECTIVE
The systematic review with meta-analysis aimed to verify the occurrence of a protective effect on hearing loss due to a higher intake of carotenoids, vitamins A, C, E, and folate present in diets.
METHODS
The search for scientific articles was carried out by 2 independent researchers in electronic databases. Meta-analysis was performed by constructing summary risk measures for each vitamin or antioxidant, combining the risk ratios or adjusted odds ratios (OR) for the various variables observed in the highest categories of vitamin or antioxidant consumption.
RESULTS
Five studies involving an estimated 100 549 participants were included in the quantitative synthesis. The summary measures calculated for the highest quartiles/quintiles of the studies were Hazard ratios (HR) .990 for vitamin C; HR 1.07 and OR .925 for vitamin E; HR .921 for folate and OR .906 for vitamin A.
CONCLUSION
Dietary intake of vitamins and antioxidants was inversely associated with the risk of developing hearing loss. Individuals with a higher intake of antioxidants may have better hearing thresholds, especially with the intake of β-carotene.
目的
本系统评价及荟萃分析旨在验证饮食中摄入较多类胡萝卜素、维生素A、C、E和叶酸对听力损失是否具有保护作用。
方法
由2名独立研究人员在电子数据库中检索科学文章。通过构建每种维生素或抗氧化剂的汇总风险测量指标进行荟萃分析，将在维生素或抗氧化剂高摄入量类别中观察到的各种变量的风险比或调整比值比（OR）合并。
结果
定量综合分析纳入了5项研究，涉及约100549名参与者。对研究中最高四分位数/五分位数计算的汇总测量指标为：维生素C的风险比（HR）为0.990；维生素E的HR为1.07，OR为0.925；叶酸的HR为0.921，维生素A的OR为0.906。
结论
维生素和抗氧化剂的饮食摄入量与发生听力损失的风险呈负相关。抗氧化剂摄入量较高的个体可能具有更好的听力阈值，尤其是摄入β-胡萝卜素时。
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