Tauqir Saman, Shah Syed S, Shah Inayat, Ali Saqib
Department of Physiology, Institute of Basic Medical Sciences, Khyber Medical University, Peshawar, Pakistan.
Department of Biomedical Dental Sciences, College of Dentistry, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
J Taibah Univ Med Sci. 2024 Oct 23;19(5):1049-1057. doi: 10.1016/j.jtumed.2024.10.002. eCollection 2024 Oct.
Exercise improves postprandial glycaemia and insulin sensitivity in individuals with prediabetes, but the optimal intensity for this metabolic regulation remains unclear. The current study aims to explore the impact of various exercise intensities on metabolic markers in prediabetic individuals to identify the optimal intensity for improving these indicators.
In this crossover study, 25 prediabetic individuals participated in exercise sessions at 50 %, 60 %, 70 %, and 80 % intensities of their predicted maximum heart rate using a treadmill. Each session lasted for 30 min, including a 5-min warm-up and a 5-min cool-down period. Blood samples were collected at four distinct time points: during fasting, immediately before exercise, and 30 and 60 min post-exercise. These samples were analyzed for glucose, insulin, and C-peptide levels. The effects of exercise intensity on these parameters were evaluated using repeated measures ANOVA, with post hoc tests conducted to determine specific differences between the intensities.
The participants had an average age of 34.88 years, a mean height of 170 cm, and a BMI of 30.34 kg/m². A significant reduction in insulin and glucose levels post-exercise was observed at 70 % intensity (p ≤ 0.001). Despite high fasting blood glucose levels (110-115 mg/dL), significant reductions were noted at 30 and 60 min post-exercise (p ≤ 0.001). Insulin levels approached near baseline at 70 % intensity, from fasting (26.74 ± 20.83) to 60 min post-exercise (28.47 ± 20.79), indicating a positive response at this intensity. C-peptide levels also showed significant changes, with the 70 % intensity exercise bringing them closest to fasting levels by 60 min post-exercise.
This study highlights the importance of exercise intensities in enhancing metabolic parameters in prediabetic individuals. Specifically, 70 % of the predicted maximum heart rate was beneficial, optimizing insulin sensitivity and potentially reducing the risk of progressing from prediabetes to diabetes.
运动可改善糖尿病前期个体的餐后血糖和胰岛素敏感性，但这种代谢调节的最佳强度仍不清楚。本研究旨在探讨不同运动强度对糖尿病前期个体代谢标志物的影响，以确定改善这些指标的最佳强度。
在这项交叉研究中，25名糖尿病前期个体使用跑步机以其预测最大心率的50%、60%、70%和80%的强度参加运动课程。每个课程持续30分钟，包括5分钟的热身和5分钟的冷却期。在四个不同时间点采集血样：空腹时、运动前即刻、运动后30分钟和60分钟。对这些样本进行葡萄糖、胰岛素和C肽水平分析。使用重复测量方差分析评估运动强度对这些参数的影响，并进行事后检验以确定不同强度之间的具体差异。
参与者的平均年龄为34.88岁，平均身高为170厘米，BMI为30.34千克/平方米。在70%强度运动后，胰岛素和葡萄糖水平显著降低（p≤0.001）。尽管空腹血糖水平较高（110 - 115毫克/分升），但在运动后30分钟和60分钟时显著降低（p≤0.001）。胰岛素水平在70%强度时接近基线水平，从空腹时的（26.74±20.83）降至运动后60分钟的（28.47±20.79），表明在此强度下有积极反应。C肽水平也显示出显著变化，70%强度的运动使它们在运动后60分钟时最接近空腹水平。
本研究强调了运动强度对改善糖尿病前期个体代谢参数的重要性。具体而言，预测最大心率的70%是有益的，可优化胰岛素敏感性并可能降低从糖尿病前期进展为糖尿病的风险。
