Department of Immunology, Mashhad University of Medical Sciences, Mashhad, Iran.
Qaen School of Nursing and Midwifery, Birjand University of Medical Sciences, Birjand, Iran.
J Drug Target. 2023 Mar;31(3):243-260. doi: 10.1080/1061186X.2022.2141755. Epub 2022 Nov 20.
Curcumin from turmeric is a natural phenolic compound with a promising potential to regulate fundamental processes involved in neurological diseases, including inflammation, oxidative stress, protein aggregation, and apoptosis at the molecular level. In this regard, employing nanoformulation can improve curcumin efficiency by reducing its limitations, such as low bioavailability. Besides curcumin, growing data suggest that stem cells are a noteworthy candidate for neurodegenerative disorders therapy due to their anti-inflammatory, anti-oxidative, and neuronal-differentiation properties, which result in neuroprotection. Curcumin and stem cells have similar neurogenic features and can be co-administered in a cell-drug delivery system to achieve better combination therapeutic outcomes for neurological diseases. Based on the evidence, curcumin can induce the neuroprotective activity of stem cells by modulating their related signalling pathways. The present review is about the role of curcumin and its nanoformulations in the improvement of neurological diseases alone and through the effect on different categories of stem cells by discussing the underlying mechanisms to provide a roadmap for future investigations.
姜黄中的姜黄素是一种天然酚类化合物，具有调节神经疾病中基本过程的巨大潜力，包括在分子水平上的炎症、氧化应激、蛋白质聚集和细胞凋亡。在这方面，采用纳米制剂可以通过减少其局限性来提高姜黄素的效率，例如低生物利用度。除了姜黄素，越来越多的数据表明，干细胞是神经退行性疾病治疗的一个值得注意的候选物，因为它们具有抗炎、抗氧化和神经元分化特性，从而导致神经保护。姜黄素和干细胞具有相似的神经发生特性，可以在细胞-药物传递系统中共给药，以实现更好的组合治疗神经疾病的效果。基于这些证据，姜黄素可以通过调节相关信号通路来诱导干细胞的神经保护活性。本综述讨论了姜黄素及其纳米制剂通过影响不同类型的干细胞来单独改善神经疾病的作用，以及通过讨论潜在机制来为未来的研究提供一个路线图。
