Cecilia Hélène, Althouse Benjamin M, Azar Sasha R, Moehn Brett A, Yun Ruimei, Rossi Shannan L, Vasilakis Nikos, Hanley Kathryn A
Department of Biology, New Mexico State University, Las Cruces, NM 88003, USA.
Information School, University of Washington, Seattle, WA 98105, USA.
iScience. 2024 Oct 19;27(11):111198. doi: 10.1016/j.isci.2024.111198. eCollection 2024 Nov 15.
Viruses transmitted by mosquitoes (e.g., dengue [DENV], Zika [ZIKV]) have demonstrated high potential to spill over from their ancestral, sylvatic cycles in non-human primates to establish transmission in humans. Epidemiological models require accurate knowledge of the contact structure between hosts and vectors, which is highly sensitive to any impacts of virus infection in mosquitoes or hosts on mosquito feeding behavior. Current evidence for whether these viruses affect vector behavior is mixed. Here we leveraged a study on sylvatic DENV-2 and ZIKV transmission between two species of monkey and to determine whether virus infection of either host or vector alters vector feeding behavior. Engorgement rates varied from 0% to 100%, but this was not driven by vector nor host infection, but rather by the individual host, host species, and host body temperature. This study highlights the importance of incorporating individual-level heterogeneity of vector biting in arbovirus transmission models.
由蚊子传播的病毒(如登革热病毒[DENV]、寨卡病毒[ZIKV])已显示出从其在非人灵长类动物中的原始丛林循环中溢出并在人类中建立传播的高潜力。流行病学模型需要准确了解宿主与媒介之间的接触结构,而这对病毒感染蚊子或宿主对蚊子取食行为的任何影响高度敏感。关于这些病毒是否影响媒介行为的现有证据不一。在此,我们利用一项关于两种猴子之间丛林型登革热病毒2型和寨卡病毒传播的研究,来确定宿主或媒介的病毒感染是否会改变媒介的取食行为。饱血率从0%到100%不等,但这并非由媒介或宿主感染驱动,而是由个体宿主、宿主物种和宿主体温决定。这项研究突出了在虫媒病毒传播模型中纳入媒介叮咬个体水平异质性的重要性。