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一项前瞻性对比研究，旨在探究富血小板血浆在雄激素性脱发患者毛发移植中的作用。

A Prospective and Comparative Study to Explore the Effects of Platelet-Rich Plasma in Hair Transplantation for Patients With Androgenetic Alopecia.

作者信息

Xue Ping, Guo Lei, Dang E, Dou Wenjie, Zeng Xianhui, Fan Xing, Yang Qing

机构信息

Department of Plastic and Reconstructive Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, People's Republic of China.

Department of Blood Transfusion, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, People's Republic of China.

出版信息

J Cosmet Dermatol. 2025 Feb;24(2):e16665. doi: 10.1111/jocd.16665. Epub 2024 Nov 18.

DOI:10.1111/jocd.16665
PMID:39555738
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11845930/
Abstract

BACKGROUND

Androgenetic alopecia (AGA) is the most prevalent type of hair loss. Traditionally, treatment for AGA has primarily involved the topical application of minoxidil in conjunction with oral finasteride or spironolactone. Recently, platelet-rich plasma (PRP) has emerged as a significant focus of research in hair loss treatment. However, many studies on PRP-assisted hair transplantation have encountered various limitations.

OBJECTIVE

This study aims to conduct a prospective, comparative clinical investigation to evaluate the therapeutic effects of combining PRP with minoxidil and finasteride/spironolactone as adjuncts to hair transplantation.

METHOD

From August 2019 to December 2022, we enrolled 30 patients with AGA in the study, randomly assigning them to an experimental group and a control group. The experimental group received drug therapy alongside hair transplantation and underwent PRP injections, whereas the control group received only drug therapy to assist with hair transplantation.

RESULTS

Prior to surgery, no significant differences in baseline data were observed between the two groups. Following treatment, the experimental group demonstrated significantly improved follicle survival rates, follicle growth rates, and hair strength compared with the control group.

CONCLUSION

This prospective, comparative clinical study demonstrated that the application of PRP in conjunction with pharmacological support during FUE treatment for AGA resulted in improved follicle survival rates, hair growth rates, and hair strength.

摘要

背景

雄激素性脱发（AGA）是最常见的脱发类型。传统上，AGA的治疗主要包括局部应用米诺地尔，同时口服非那雄胺或螺内酯。最近，富血小板血浆（PRP）已成为脱发治疗研究的一个重要焦点。然而，许多关于PRP辅助植发的研究都遇到了各种局限性。

目的

本研究旨在进行一项前瞻性、对比性临床研究，以评估PRP与米诺地尔和非那雄胺/螺内酯联合作为植发辅助手段的治疗效果。

方法

2019年8月至2022年12月，我们招募了30例AGA患者参与研究，将他们随机分为实验组和对照组。实验组在植发的同时接受药物治疗并进行PRP注射，而对照组仅接受药物治疗以辅助植发。

结果

手术前，两组的基线数据无显著差异。治疗后，实验组的毛囊存活率、毛囊生长率和头发强度均显著高于对照组。

结论

这项前瞻性、对比性临床研究表明，在AGA的毛囊单位提取植发（FUE）治疗中，PRP与药物支持联合应用可提高毛囊存活率、头发生长率和头发强度。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72f7/11845930/5e637264c1eb/JOCD-24-e16665-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72f7/11845930/292021ecc1d7/JOCD-24-e16665-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72f7/11845930/614f1f4f40f1/JOCD-24-e16665-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72f7/11845930/5c43a425b1e5/JOCD-24-e16665-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72f7/11845930/5e637264c1eb/JOCD-24-e16665-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72f7/11845930/292021ecc1d7/JOCD-24-e16665-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72f7/11845930/614f1f4f40f1/JOCD-24-e16665-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72f7/11845930/5c43a425b1e5/JOCD-24-e16665-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72f7/11845930/5e637264c1eb/JOCD-24-e16665-g004.jpg

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本文引用的文献

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Preparation of Platelet-Rich Plasma: National IADVL PRP Taskforce Recommendations.富血小板血浆的制备：国际皮肤性病学会富血小板血浆特别工作组国家推荐意见
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