Zoglio Virginia, de Lima Joana Esteves, Relaix Frédéric
Université Paris Est Créteil, Inserm, EnvA, EFS, AP-HP, IMRB, Créteil, France.
Med Sci (Paris). 2024 Nov;40 Hors série n° 1:56-59. doi: 10.1051/medsci/2024139. Epub 2024 Nov 18.
PAX3 plays a crucial role in embryonic myogenesis, controlling the specification, migration, proliferation, and differentiation of muscle progenitor cells to ensure normal skeletal muscle development in the embryo. However, PAX3 potential role in a context of muscle homeostasis and regeneration remains poorly investigated. The adult muscle stem cells, known as satellite cells (SCs) exhibit heterogeneity in Pax3 expression in various muscles throughout the body and display a bimodal response to environmental stress exposure. To explore the role of PAX3 in the context of tissue damage, we performed regeneration studies, which unveiled a functional heterogeneity of the SCs populations depending on Pax3 expression. Together, this project aims to decipher cell-type specific dysregulations linked to tissue damage and identify PAX3 downstream gene regulatory networks that can lead to specific SC behavior, thus potentially providing novel strategies for muscle disease preventive therapies.
PAX3在胚胎肌生成过程中发挥着关键作用，它控制着肌肉祖细胞的特化、迁移、增殖和分化，以确保胚胎中正常的骨骼肌发育。然而，PAX3在肌肉稳态和再生环境中的潜在作用仍未得到充分研究。成年肌肉干细胞，即卫星细胞（SCs），在全身不同肌肉中Pax3表达存在异质性，并且对环境应激暴露表现出双峰反应。为了探究PAX3在组织损伤环境中的作用，我们进行了再生研究，结果揭示了SCs群体根据Pax3表达存在功能异质性。总之，该项目旨在破译与组织损伤相关的细胞类型特异性失调，并确定可导致特定SCs行为的PAX3下游基因调控网络，从而有可能为肌肉疾病预防性治疗提供新策略。
