Rigney D R
Cell Tissue Kinet. 1986 Jan;19(1):23-37. doi: 10.1111/j.1365-2184.1986.tb00712.x.
Cell cycle models that allow multiple random transitions and asymmetric cell division may exhibit a property that has been used to support the transition probability model of the cell cycle: that the absolute value of the difference between sibling cell inter-mitotic times varies from one sibling pair to another and is described by an exponential statistical distribution. Three models that show this property are described, each of which postulates the existence of objects that are partitioned between daughter cells during cell division and whose number influences the duration of the subsequent cell cycle, e.g., surface receptors for growth factors or transcriptional complexes that are carried by sister chromatids. In the first model, sibling cells receive identical numbers of the objects, which are used to perform multiple random transitions that constitute part of the cell cycle. The second model is like the first, except that the partitioning of objects between the newly-formed sibling cells is random. The third model is also like the first, except that all of the objects are passed to one of the sibling cells. These results show that the general mechanisms that are responsible for the dispersion of inter-mitotic times, the correlation between sibling generation times and the apparently exponentially distributed difference between sibling generation times, could be a combination of unequal cell division, multiple random cell cycle transitions and heterogeneity of mitotic cells.
允许多次随机转变和不对称细胞分裂的细胞周期模型可能展现出一种特性，该特性已被用于支持细胞周期的转变概率模型：即姐妹细胞有丝分裂间隔时间之间差异的绝对值在不同姐妹细胞对之间各不相同，且由指数统计分布来描述。本文描述了三种展现此特性的模型，每个模型都假定在细胞分裂过程中存在会在子细胞间进行分配的物体，且这些物体的数量会影响后续细胞周期的持续时间，例如，生长因子的表面受体或由姐妹染色单体携带的转录复合物。在第一个模型中，姐妹细胞接收相同数量的这些物体，这些物体用于执行构成细胞周期一部分的多次随机转变。第二个模型与第一个类似，只是新形成的姐妹细胞之间物体的分配是随机的。第三个模型也与第一个类似，只是所有物体都传递给其中一个姐妹细胞。这些结果表明，导致有丝分裂间隔时间离散、姐妹细胞生成时间之间的相关性以及姐妹细胞生成时间之间明显呈指数分布的差异的一般机制，可能是不等细胞分裂、多次随机细胞周期转变和有丝分裂细胞异质性的组合。
