Desai Nihar R, Lopalco Pier L
Section of Cardiovascular Medicine Center for Outcomes Research Evaluation (CORE), Yale University School of Medicine, New Haven, CT, USA.
Department of Experimental Medicine, University of Salento, Lecce, Italy.
Adv Ther. 2025 Jan;42(1):1-9. doi: 10.1007/s12325-024-03021-6. Epub 2024 Nov 18.
Despite well-established vaccination programs, seasonal influenza is still causing substantial clinical, economic and societal burdens. As part of strategies to continually improve influenza vaccine clinical performance, several new approaches are being examined, including high-dose vaccines, adjuvanted vaccines, egg-free vaccines, nasal spray vaccines and mRNA vaccines. Given this range of influenza vaccines, coupled with various vaccine hesitancy concerns, healthcare professionals' understanding and confidence in the clinical performance of influenza vaccines remain key. In this podcast, we discuss the challenges for healthcare professionals in understanding the clinical performance of influenza vaccines and the importance of education in this area, particularly to address perceptions of influenza vaccine failure. We also explore several elements that should be considered in the assessment of influenza vaccine clinical performance: (1) assessing relevant clinical outcomes, such as hospitalization data, (2) utilizing robust methodology in influenza vaccine trials to ensure high quality evidence and (3) approaches used when considering the full body of evidence.
尽管有成熟的疫苗接种计划，但季节性流感仍在造成巨大的临床、经济和社会负担。作为不断提高流感疫苗临床性能策略的一部分，正在研究几种新方法，包括高剂量疫苗、佐剂疫苗、无蛋疫苗、鼻喷疫苗和mRNA疫苗。鉴于有如此多种流感疫苗，再加上各种疫苗犹豫问题，医疗保健专业人员对流感疫苗临床性能的理解和信心仍然至关重要。在本播客中，我们讨论了医疗保健专业人员在理解流感疫苗临床性能方面面临的挑战，以及该领域教育的重要性，特别是为了解决对流感疫苗失效的看法。我们还探讨了评估流感疫苗临床性能时应考虑的几个要素：（1）评估相关临床结果，如住院数据；（2）在流感疫苗试验中采用稳健的方法以确保高质量证据；（3）考虑全部证据时所使用的方法。
