Gogoi Monti, Goswami Rajiv, Borah Akhil Ranjan, Phukan Lachit, Hazarika Swapnali
Chemical Engineering Group and Centre for Petroleum Research, CSIR-North East Institute of Science and Technology, Jorhat, Assam, India.
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India.
Biomed Chromatogr. 2025 Jan;39(1):e6043. doi: 10.1002/bmc.6043. Epub 2024 Nov 18.
In the past decade, significant advances have been made in the field of chiral separation, which is crucial for biological and pharmaceutical applications. Enantioselective membranes have emerged as a promising platform for efficient chiral separation due to their unique properties such as large surface area, tunable pore size, and high selectivity. These membranes are particularly effective in separating enantiomers because of their ability to facilitate selective interactions between the membrane material and chiral molecules. This article provides a comprehensive review of the recent progress in enantioselective membranes for chiral separation. Key topics discussed include various membrane fabrication methods, functionalization approaches, and the characterization of membrane properties, specifically in the context of applications like drug delivery, biomolecule separation, and pharmaceutical analysis. Furthermore, the review addresses the current challenges, potential solutions, and future prospects in this rapidly evolving field, highlighting the direction for upcoming research.
在过去十年中，手性分离领域取得了重大进展，这对于生物和制药应用至关重要。对映选择性膜因其具有大表面积、可调孔径和高选择性等独特性质，已成为高效手性分离的一个有前景的平台。这些膜在分离对映体方面特别有效，因为它们能够促进膜材料与手性分子之间的选择性相互作用。本文全面综述了用于手性分离的对映选择性膜的最新进展。讨论的关键主题包括各种膜制备方法、功能化方法以及膜性质的表征，特别是在药物递送、生物分子分离和药物分析等应用背景下。此外，该综述还探讨了这个快速发展领域当前面临的挑战、潜在解决方案和未来前景，突出了未来研究的方向。
