Teng Yan, Gu Chenglu, Chen Zhuhui, Jiang Hui, Xiong Yue, Liu Dong, Xiao Deli
Department of Analytical Chemistry, China Pharmaceutical University, Nanjing, China.
Anhui Engineering Laboratory for Conservation and Sustainable Utilization of Traditional Chinese Medicine Resources, School of Biological and Pharmaceutical Engineering, West Anhui University, Liu'an, China.
Chirality. 2022 Aug;34(8):1094-1119. doi: 10.1002/chir.23453. Epub 2022 Jun 8.
The attention to chiral drugs has been raised to an unprecedented level as drug discovery and development strategies grow rapidly. However, separation of enantiomers is still a huge task, which leads to an increasing significance to equip a wider range of expertise in chiral separation science to meet the current and future challenges. In the last few decades, remarkable progress of chiral resolution has been achieved. This review summarizes and classifies chiral resolution methods in analytical scale and preparative scale systematically and comprehensively, including crystallization-based method, inclusion complexation, chromatographic separation, capillary electrophoresis, kinetic resolution, liquid-liquid extraction, membrane-based separation, and especially one bold new progress based on chiral-induced spin selectivity theory. The advances and recent applications will be presented in detail, in which the contents may bring more thinking to wide-ranging readers in various professional fields, from analytical chemistry, pharmaceutical chemistry, natural medicinal chemistry, to manufacturing of drug production.
随着药物发现和开发策略的迅速发展，对手性药物的关注已提升到前所未有的高度。然而，对映体的分离仍然是一项艰巨的任务，这使得配备更广泛的手性分离科学专业知识以应对当前和未来的挑战变得越来越重要。在过去几十年中，手性拆分取得了显著进展。本文系统全面地总结并分类了分析规模和制备规模的手性拆分方法，包括基于结晶的方法、包合络合、色谱分离、毛细管电泳、动力学拆分、液液萃取、基于膜的分离，尤其是基于手性诱导自旋选择性理论的一项大胆新进展。将详细介绍这些进展和最新应用，其中的内容可能会给从分析化学、药物化学、天然药物化学到药物生产制造等各个专业领域的广大读者带来更多思考。
