Research Center for Social Determinants of Health, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Biostatistics, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran , Iran.
BMJ Open. 2024 Nov 18;14(11):e087870. doi: 10.1136/bmjopen-2024-087870.
The current study aimed to investigate the associations between metabolic syndrome (MetS) with health-related quality of life (HRQoL) using multilevel analysis among the Iranian adult population.
This cross-sectional study was conducted in the framework of the Tehran Lipid and Glucose Study (TLGS). Participants were 6113 participants (3318 women and 2795 men) aged≥20 years of the TLGS seventh phase who had completed data on HRQoL and MetS. HRQoL was assessed using the short-form 12-item health survey V.2 and MetS defined based on the guidelines outlined in the Joint Interim Statement. The two-level model was fitted to assess the association between MetS and HRQoL.
The prevalence of MetS and its components was higher in men, and regardless of metabolic status, men exhibited higher HRQoL values. The deleterious impact of MetS on HRQoL was more pronounced in women, while the detrimental effects of MetS on men's HRQoL were confined to specific subscales. These results were obtained through multilevel analysis, considering both familial and individual variation levels. Moreover, our investigation highlighted the positive influence of leisure-time physical activity on both the physical and mental component summaries (PCS and MCS, respectively), regardless of gender. Education had a greater positive impact on PCS in both sexes. Additionally, a history of cardiovascular diseases was associated with a decline in mental and physical HRQoL, while age was linked to a decline in PCS and MCS, and smoking was associated with a decline in MCS.
This study revealed the significant influence of gender, as well as the unique characteristics and circumstances of individuals, on the relationship between MetS and HRQoL in a general population with low/middle income.
本研究旨在通过伊朗成年人群体的多层次分析，探讨代谢综合征（MetS）与健康相关生活质量（HRQoL）之间的关系。
本横断面研究是在德黑兰血脂和血糖研究（TLGS）框架内进行的。参与者为 TLGS 第七阶段的 6113 名年龄≥20 岁的受试者，他们完成了 HRQoL 和 MetS 的数据。使用 12 项简明健康调查短表 V.2 评估 HRQoL，MetS 按照联合临时声明中概述的指南定义。拟合两水平模型评估 MetS 与 HRQoL 之间的关系。
无论代谢状态如何，男性的 MetS 及其组分的患病率均较高，且男性的 HRQoL 值较高。MetS 对女性 HRQoL 的不利影响更为明显，而 MetS 对男性 HRQoL 的不利影响仅限于特定子量表。这些结果是通过多层次分析得出的，同时考虑了家族和个体变异水平。此外，我们的研究还强调了休闲时间体育活动对男性和女性的生理和心理成分综合评分（PCS 和 MCS）的积极影响。教育对男性和女性的 PCS 都有更大的积极影响。此外，心血管疾病史与心理和生理 HRQoL 的下降有关，而年龄与 PCS 和 MCS 的下降有关，吸烟与 MCS 的下降有关。
本研究揭示了性别以及个体的独特特征和情况对中低收入普通人群中 MetS 与 HRQoL 之间关系的重要影响。
