Liu Yulong, Li Ya, Jiao Liqin, Kang Yefang, Du Baojie, Cai Wenwen, Cui Hong, Zhang Ruiping
General Surgery Department, Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan 030032, China.
Department of School of Public Health, Shanxi Medical University, Taiyuan 030001, China.
ACS Appl Mater Interfaces. 2024 Dec 4;16(48):65907-65917. doi: 10.1021/acsami.4c14909. Epub 2024 Nov 18.
Wound infections have gradually become a major threat to human health. Recently, covalent organic frameworks (COFs) have shown great potential in antibacterial and wound healing; however, difficult biodegradability and long-time retention limit their further application. Herein, biodegradable COFs containing porphyrin backbones and hypoxia-sensitive azobenzene group, namely, HRCOFs, are fabricated for photodynamic therapy (PDT) and photothermal therapy (PTT) of wound infection. Due to the introduction of a porphyrin molecule, HRCOFs can produce singlet oxygen (O) under 660 nm laser irradiation. The prepared HRCOFs can also generate thermal energy under 808 nm NIR laser irradiation. HRCOFs show excellent synergetic antibacterial ability against and . The experiments also demonstrate synergistic PDT and PTT effects of HRCOFs against wound infection. Importantly, HRCOFs are response to wound microenvironment, can be degraded for clearance, and avoid some adverse effects caused by long-time retention , exhibiting good biocompatibility. In general, the obtained biodegradable HRCOFs with both photodynamic and photothermal effects can be used for antibacterial infections and provide great value for promoting wound healing.
伤口感染已逐渐成为对人类健康的重大威胁。近年来，共价有机框架（COFs）在抗菌和伤口愈合方面展现出巨大潜力；然而，其难生物降解性和长时间留存限制了它们的进一步应用。在此，制备了含卟啉骨架和缺氧敏感偶氮苯基团的可生物降解COFs，即HRCOFs，用于伤口感染的光动力疗法（PDT）和光热疗法（PTT）。由于引入了卟啉分子，HRCOFs在660 nm激光照射下可产生单线态氧（O）。制备的HRCOFs在808 nm近红外激光照射下也能产生热能。HRCOFs对[具体细菌名称1]和[具体细菌名称2]显示出优异的协同抗菌能力。实验还证明了HRCOFs对伤口感染的协同光动力和光热效应。重要的是，HRCOFs对伤口微环境有响应，可降解以清除，避免了长时间留存引起的一些不良反应，表现出良好的生物相容性。总体而言，所获得的具有光动力和光热效应的可生物降解HRCOFs可用于抗菌感染，为促进伤口愈合提供巨大价值。
