Balu Sucharitha, Huget Susie, Medina Reyes Juan Jose, Ragueneau Eliot, Panneerselvam Kalpana, Fischer Samantha N, Claussen Erin R, Kourtis Savvas, Combe Colin W, Meldal Birgit H M, Perfetto Livia, Rappsilber Juri, Kustatscher Georg, Drew Kevin, Orchard Sandra, Hermjakob Henning
European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
Department of Biological Sciences, University of Illinois at Chicago, Chicago, IL 60607, USA.
Nucleic Acids Res. 2025 Jan 6;53(D1):D644-D650. doi: 10.1093/nar/gkae1085.
The Complex Portal (www.ebi.ac.uk/complexportal) is a manually curated reference database for molecular complexes. It is a unifying web resource linking aggregated data on composition, topology and the function of macromolecular complexes from 28 species. In addition to significantly extending the number of manually curated complexes, we have massively extended the coverage of the human complexome through the incorporation of high confidence assemblies predicted by machine-learning algorithms trained on large-scale experimental data. The current content of the portal comprising 2150 human complexes has been augmented by 14 964 machine-learning (ML) predicted complexes from hu.MAP3.0. We have refactored the website to enable easy search and filtering of these different classes of protein complexes and have implemented the Complex Navigator, a visualisation tool to facilitate comparison of related complexes in the context of orthology or paralogy. We have embedded the Rhea reaction visualisation tool into the website to enable users to view the catalytic activity of enzyme complexes.
